Xu Xiaohong, Zhang Yufan, Zhang Xueyuan
Chaozhou Institute for Drug Control, Chaozhou 521000, China.
College of Pharmacy, Graduate School, Sun Yat-Sen University, Shenzhen 518107, China.
Molecules. 2024 Nov 25;29(23):5553. doi: 10.3390/molecules29235553.
Developing efficient and novel methodologies to construct a C-C bond is highly important in both synthetic chemistry and pharmaceutical sciences. In recent years, the visible light-mediated desulfonylative transformation of sulfonyl compounds has emerged as a powerful tool for the synthesis of diverse C-C bond. To emphasize their practical utility, many methodologies have been successfully applied in the modification of a variety of biologically active compounds which possess unprotected amide or hydroxy groups. In this review, we would like to summarize recent advances in C-C bond formation via the visible light-mediated desulfonylation of sulfonyl chlorides, sulfinates, sulfonamides, sulfones, and sulfonylhydrazones. The reaction design, mechanism research, and the application of these protocols in the modification of biologically active compounds are presented. The challenges and future developments in this area are also discussed.
开发高效且新颖的构建碳-碳键的方法在合成化学和药物科学领域都极为重要。近年来，可见光介导的磺酰基化合物脱磺酰化转化已成为合成各种碳-碳键的有力工具。为强调其实际应用价值，许多方法已成功应用于对多种具有未保护酰胺或羟基的生物活性化合物的修饰。在本综述中，我们将总结通过可见光介导的磺酰氯、亚磺酸盐、磺酰胺、砜和磺酰腙的脱磺酰化形成碳-碳键的最新进展。介绍了这些反应的设计、机理研究以及它们在生物活性化合物修饰中的应用。还讨论了该领域面临的挑战和未来发展。
