Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA,
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Nephron. 2023;147(1):25-30. doi: 10.1159/000526265. Epub 2022 Oct 4.
Recent studies have demonstrated an important role played by gut microbiota in maintaining intestinal homeostasis and host immune system function. Gut microbiota have been studied in experimental acute kidney injury (AKI) using different mice and rat models exposed to either ischemia or cisplatin-mediated tubular injury. Differences in inflammatory markers and severity of AKI have been observed between germ-free mice, wild-type mice, and mice treated with antibiotics or specific bacteria. Interventions modifying the gut microbiota after experimental AKI have had either beneficial or harmful effects on kidney tubular injury and recovery. These findings provide strong evidence for a modulatory role of gut microbiota during AKI. Ischemic and cis-platin-induced AKI have distinct stool microbial signatures based on 16s sequencing. Future in-depth studies exploring the mechanisms of how the microbiota influence AKI and development of feasible therapeutic options have the potential to improve outcomes in clinical AKI.
最近的研究表明，肠道微生物群在维持肠道内环境平衡和宿主免疫系统功能方面发挥着重要作用。使用不同的小鼠和大鼠模型，通过缺血或顺铂介导的肾小管损伤来研究肠道微生物群在实验性急性肾损伤（AKI）中的作用。在无菌小鼠、野生型小鼠和用抗生素或特定细菌处理的小鼠之间，观察到炎症标志物和 AKI 严重程度存在差异。在实验性 AKI 后干预肠道微生物群，对肾小管损伤和恢复有有益或有害的影响。这些发现为肠道微生物群在 AKI 中的调节作用提供了有力证据。基于 16s 测序，缺血性和顺铂诱导的 AKI 具有不同的粪便微生物特征。未来深入研究探索微生物如何影响 AKI 和可行治疗选择的发展，有可能改善临床 AKI 的结局。
