Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa 920-1192, Japan.
Division of Infection Control, Kanazawa University Hospital, Kanazawa 920-1192, Japan.
Toxins (Basel). 2021 May 22;13(6):369. doi: 10.3390/toxins13060369.
Recent studies have revealed that the gut microbiota plays a crucial role in maintaining a healthy, as well as diseased condition. Various organs and systems, including the kidney, are affected by the gut microbiota. While the impacts of the gut microbiota have been reported mainly on chronic kidney disease, acute kidney injury (AKI) is also affected by the intestinal environment. In this review, we discussed the pathogenesis of AKI, highlighting the relation to the gut microbiota. Since there is no established treatment for AKI, new treatments for AKI are highly desired. Some kinds of gut bacteria and their metabolites reportedly have protective effects against AKI. Current studies provide new insights into the role of the gut microbiota in the pathogenesis of AKI.
最近的研究表明，肠道微生物群在维持健康和疾病状态方面起着至关重要的作用。各种器官和系统，包括肾脏，都受到肠道微生物群的影响。虽然肠道微生物群的影响主要报道在慢性肾脏病上，但急性肾损伤（AKI）也受到肠道环境的影响。在这篇综述中，我们讨论了 AKI 的发病机制，强调了与肠道微生物群的关系。由于目前没有针对 AKI 的既定治疗方法，因此非常需要针对 AKI 的新治疗方法。一些种类的肠道细菌及其代谢产物据称对 AKI 具有保护作用。目前的研究为肠道微生物群在 AKI 发病机制中的作用提供了新的见解。
