Cechin Laura, Norcross Claire, Oliveira Amelia, Hopkins David, McGowan Barbara, Post Frank A
King's College Hospital NHS Foundation Trust, London, UK.
University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
HIV Med. 2023 Apr;24(4):380-388. doi: 10.1111/hiv.13413. Epub 2022 Oct 4.
Obesity is a chronic disease with multiple adverse effects on health. The prevalence of obesity is increasing worldwide, and people of African ancestry are disproportionally affected. Several widely used antiretrovirals have been associated with weight gain and contribute to the rising burden of obesity in people with HIV. Obesity and weight gain on antiretroviral therapy are risk factors for the development of type 2 diabetes mellitus, a condition which also disproportionally affects black populations. In this review, we discuss recent data on weight gain in relation to initiating or switching antiretroviral therapy and advances in the management of obesity. Availability of highly effective treatments for obesity have the potential to address, and potentially reverse, the epidemics of obesity and diabetes mellitus in people with HIV.
肥胖是一种对健康有多种不良影响的慢性疾病。肥胖在全球范围内的患病率正在上升，非洲裔人群受到的影响尤为严重。几种广泛使用的抗逆转录病毒药物与体重增加有关，并加重了艾滋病毒感染者的肥胖负担。肥胖以及抗逆转录病毒治疗导致的体重增加是2型糖尿病发生的危险因素，而2型糖尿病对黑人人群的影响也尤为严重。在本综述中，我们讨论了与开始或更换抗逆转录病毒治疗相关的体重增加的最新数据以及肥胖管理方面的进展。高效肥胖治疗方法的出现有可能解决并潜在逆转艾滋病毒感染者中的肥胖和糖尿病流行问题。
