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韩国HIV感染患者肾功能不全的发病率及危险因素:韩国HIV/AIDS队列研究

The Incidence and Risk Factors of Renal Insufficiency among Korean HIV infected Patients: The Korea HIV/AIDS Cohort Study.

作者信息

Kim Jun Hyoung, Jang Heeseon, Kim Jung Ho, Song Joon Young, Kim Shin-Woo, Kim Sang Il, Choi Bo Youl, Choi Jun Yong

机构信息

Division of Infectious Diseases, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Infect Chemother. 2022 Sep;54(3):534-541. doi: 10.3947/ic.2022.0101.

Abstract

Renal insufficiency is one of the common issues in people living with human immunodeficiency virus (PLHIV). We studied the incidence and risk factors for renal insufficiency in male PLHIV using the Korea HIV/acquired immunodeficiency syndrome (AIDS) Cohort Study. Among the 830 enrolled patients, 32 (3.9%) cases of renal insufficiency occurred over 9576 patient-years of follow-up. The incidence of renal insufficiency in HIV-infected men in this study was 3.3 per 1000 patient-years. Diabetes mellitus, dyslipidemia, tenofovir or non-nucleoside reverse transcriptase inhibitor exposure for >1 year, and AIDS-defining illness were risk factors for renal insufficiency.

摘要

肾功能不全是人类免疫缺陷病毒(HIV)感染者中的常见问题之一。我们利用韩国HIV/获得性免疫缺陷综合征(AIDS)队列研究,对男性HIV感染者肾功能不全的发病率及危险因素进行了研究。在830名登记患者中,在9576患者年的随访期间发生了32例(3.9%)肾功能不全病例。本研究中HIV感染男性肾功能不全的发病率为每1000患者年3.3例。糖尿病、血脂异常、使用替诺福韦或非核苷类逆转录酶抑制剂超过1年以及艾滋病界定疾病是肾功能不全的危险因素。

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