13 Brenner tumors were studied clinicomorphologically. The tumor nests are once again shown to arise in the benign variant due to the proliferation of the mucose-forming epithelium in the cysts with one-layer lining. Morphogenesis of the papillary structures in the border-line variety of the tumor is demonstrated. Three observations of the malignant Brenner tumors are described in which the relation to the preexisting nests of the benign analogue is proved. The hypothesis is proposed on the analogy of the morphogenetic mechanisms of the Brenner tumor structures formation with the processes of the proliferation of cervical channel cambial cells with their successive epidermization. It is suggested that the combination of mucinous cysts with Brenner tumor nests is one and the same process.
对13例勃勒纳瘤进行了临床形态学研究。肿瘤巢再次显示出源于良性变体,这是由于单层衬里囊肿中形成黏液的上皮细胞增殖所致。展示了肿瘤交界性类型中乳头状结构的形态发生。描述了3例恶性勃勒纳瘤的观察结果,其中证实了其与良性类似物先前存在的巢之间的关系。基于勃勒纳瘤结构形成的形态发生机制与宫颈管形成层细胞增殖并相继表皮化过程的类比,提出了这一假说。提示黏液性囊肿与勃勒纳瘤巢的结合是同一过程。