Department of Pediatric Surgery, The First People's Hospital of Lianyungang, Lianyungang Hospital Affiliated to Xuzhou Medical University, The Affiliated Hospital of Kangda College, Nanjing Medical University, Lianyungang, Jiangsu, China.
Medicine (Baltimore). 2022 Sep 23;101(38):e30743. doi: 10.1097/MD.0000000000030743.
To evaluate the relationship between the expression level of (MCP-1) in peripheral blood and the short-term recurrence of primary intussusception in children, a retrospective analysis of children with primary intussusception under ultrasound-guided hydrostatic reduction in our hospital from June 2019 to June 2021, a total of 412 cases, 37 cases of short-term recurrence. Enzyme-linked immunosorbent assay was used to detect the expression of MCP-1 in peripheral venous blood; receiver operating curve (ROC) was utilized to evaluate the diagnostic efficacy of MCP-1 in predicting short-term recurrence; logistic regression analysis of risk factors for recurrence. MCP-1 increased in the peripheral blood of children with short-term recurrence (P < .05). Logistic regression analysis found that increased MCP-1 was a risk factor for recurrence; ROC showed that 23.24 ng/mL was used as a cut-off value. The sensitivity of MCP-1 for predicting the recurrence of intussusception in children is 82.14%, and the specificity is 75.67%. In primary intussusception, the expression of MCP-1 in the peripheral blood of children with short-term recurrence is raised. Elevated expression of MCP-1 is a risk factor for predicting short-term intussusception recurrence and has certain clinical significance.
为了评估外周血中（MCP-1）表达水平与儿童原发性肠套叠短期复发之间的关系，我们对 2019 年 6 月至 2021 年 6 月在我院接受超声引导下水压复位的原发性肠套叠患儿进行了回顾性分析，共 412 例，其中 37 例出现短期复发。采用酶联免疫吸附试验检测外周静脉血中 MCP-1 的表达；利用受试者工作特征曲线（ROC）评估 MCP-1 预测短期复发的诊断效能；对复发的危险因素进行 logistic 回归分析。结果显示，短期复发患儿外周血中 MCP-1 升高（P<0.05）。logistic 回归分析发现，MCP-1 升高是复发的危险因素；ROC 显示，23.24ng/mL 作为截断值时，MCP-1 预测儿童肠套叠复发的敏感性为 82.14%，特异性为 75.67%。在原发性肠套叠中，短期复发患儿外周血中 MCP-1 的表达升高。MCP-1 表达升高是预测短期肠套叠复发的危险因素，具有一定的临床意义。
