Universidade Federal do Triângulo Mineiro (UFTM), Instituto de Ciências Biológicas e Naturais, Rua Vigário Carlos, 100, Abadia, 38025-350 Uberaba, MG, Brazil.
Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Ortopedia e Anestesiologia, Av. Bandeirantes, 3900, Campus Universitário, Monte Alegre, 14048-900 Ribeirão Preto, SP, Brazil.
An Acad Bras Cienc. 2022 Oct 3;94(suppl 3):e20210661. doi: 10.1590/0001-3765202220210661. eCollection 2022.
Excessive alcohol consumption is considered a risk factor for bone health, as it causes a reduction in mass and increases the risk of fracture. However, the determination of bone mineral density (BMD) has not always been an adequate predictor of bone fragility. Thus, the hypothesis arises that chronic alcohol consumption interferes with collagen synthesis and the quality of bone trabeculae, with consequent bone fragility. Groups: Control (n = 6; water intake only during the entire study period); Ethanol (n = 6; ingestion of ethyl alcohol according to the protocol for inducing chronic alcohol consumption). The chronic alcohol consumption model did not cause a significant change in BMD, but there was a significant reduction of 20% in the thickness of the bone trabeculae and of 1.56% in the collagen located in the neck region of immature rat femurs. Although there was no significant change in the mineral matrix, the changes in the organic matrix were able to provide a significant reduction in bone strength. The results suggest harmful effects of alcohol intake on the bone quality of young adult animals and draw attention to the need to also consider methods for the diagnosis of collagen as an element of bone fragility.
过量饮酒被认为是骨骼健康的一个风险因素，因为它会导致骨量减少，并增加骨折的风险。然而，骨密度（BMD）的测定并不总是骨骼脆弱的充分预测指标。因此，出现了这样一种假设，即慢性酒精摄入会干扰胶原蛋白的合成和骨小梁的质量，从而导致骨骼脆弱。
对照组（n = 6；在整个研究期间仅摄入水）；乙醇组（n = 6；根据诱导慢性酒精摄入的方案摄入乙醇）。慢性酒精摄入模型并没有导致 BMD 显著变化，但骨小梁厚度显著减少了 20%，未成年大鼠股骨颈部的胶原蛋白减少了 1.56%。尽管矿物质基质没有显著变化，但有机基质的变化能够显著降低骨强度。研究结果表明，酒精摄入对年轻成年动物的骨骼质量有不良影响，并提醒人们需要考虑将胶原蛋白作为骨骼脆弱的一个因素来诊断。
