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老年患者的微创瓣膜手术-安全性、早期恢复和长期结果。

Minimally Invasive Valvular Surgery in the Elderly - Safety, Early Recovery, and Long-Term Outcomes.

机构信息

Department of Cardiovascular Surgery, Nagasaki University Hospital.

出版信息

Circ J. 2022 Oct 25;86(11):1725-1732. doi: 10.1253/circj.CJ-22-0338. Epub 2022 Oct 5.

Abstract

BACKGROUND

For elderly people, the benefit of minimally invasive cardiac surgery (MICS) is unclear, so we evaluated the safety, recovery, and long-term survival in elderly MICS patients.

METHODS AND RESULTS

63 propensity score-matched pairs of 213 consecutive patients (≥70 years old) who underwent mitral and/or tricuspid valve surgery between 2010 and 2020 (121 right mini-thoracotomies vs. 92 full sternotomies) were compared. The primary outcome was safety (composite endpoint of in-hospital death or major complication). Secondary outcomes were early ambulation and discharge to home. There were no differences between the groups for in-hospital death (3.2% vs. 0.0%, P=0.157) and primary outcome (14.3% vs. 17.5%, P=0.617). The rate of early ambulation (73.0% vs. 55.6%, P=0.048) and discharge to home (66.7% vs. 49.2%, P=0.034) were significantly higher in the mini-thoracotomy group. Major complication was an independent negative predictor of early ambulation for mini-thoracotomy but not for a conservative approach. Survival was 87.8±4.4% vs. 86.8±4.7% at 5 years, which was not significantly different.

CONCLUSIONS

Similar safety but better recovery were observed for mini-thoracotomy, and long-term survival was comparable between groups. Major complication was a negative predictor of early ambulation after mini-thoracotomy. Careful preoperative risk stratification would enhance the benefits of MICS in elderly patients.

摘要

背景

对于老年人来说,微创心脏手术(MICS)的益处尚不清楚,因此我们评估了老年 MICS 患者的安全性、恢复情况和长期生存情况。

方法和结果

比较了 2010 年至 2020 年间连续 213 例(≥70 岁)接受二尖瓣和/或三尖瓣手术的患者(121 例右迷你开胸术与 92 例全胸骨切开术)的 63 对倾向评分匹配对。主要结局是安全性(住院期间死亡或主要并发症的复合终点)。次要结局是早期活动和出院回家。两组在住院期间死亡率(3.2%比 0.0%,P=0.157)和主要结局(14.3%比 17.5%,P=0.617)方面无差异。迷你开胸组早期活动(73.0%比 55.6%,P=0.048)和出院回家(66.7%比 49.2%,P=0.034)的比例显著更高。主要并发症是迷你开胸术早期活动的独立负预测因子,但对保守治疗则不然。5 年生存率为 87.8±4.4%比 86.8±4.7%,无显著差异。

结论

迷你开胸术具有相似的安全性,但恢复更好,两组的长期生存情况无显著差异。主要并发症是迷你开胸术后早期活动的负面预测因子。术前仔细的风险分层将提高 MICS 在老年患者中的益处。

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