Hunan University of Chinese Medicine.
Department of Vascular Surgery, The Second Xiangya Hospital of Central South University.
J Oleo Sci. 2022 Oct 28;71(11):1613-1624. doi: 10.5650/jos.ess22056. Epub 2022 Oct 5.
Diet is the most direct and rapid contributor to the gut microbiome. Oils and fats are important nutrients in the human body. The effects of lard or vegetable blend oil on gut microbiota were investigated. Kunming mice were given lard or vegetable blend oil for six weeks. Changes in microbiota composition and abundance in lard or vegetable blend oil diets were analyzed by 16S rRNA gene amplicon sequencing. Our study shows that the gut microbiota of mice changed significantly after ingestion of lard or vegetable blend oil. Lard may synergize with Coriobacteriaceae_UCG-002. Vegetable blend oil has synergistic effects with Akkermansia, Roseburia, and Enteractinococcus. Coriobacteriaceae_UCG-002 showed a significant negative correlation with Glycolysis/Gluconeogenesis. Roseburia was most strongly associated with Starch and sucrose metabolism. According to bacterial function prediction and correlation analysis, long-term consumption of lard or vegetable oil may affect glycolipid metabolism, but lard has a greater impact on human health and consequently host health.
饮食是对肠道微生物组影响最直接和快速的因素。油脂是人体重要的营养素。本研究旨在探讨猪油或植物调和油对肠道微生物群的影响。昆明小鼠给予猪油或植物调和油 6 周。通过 16S rRNA 基因扩增子测序分析猪油或植物调和油饮食中微生物组成和丰度的变化。我们的研究表明，小鼠摄入猪油或植物调和油后肠道微生物群发生了显著变化。猪油可能与科里氏菌科 UCG-002 协同作用。植物调和油与阿克曼氏菌、罗塞尔氏菌和肠球菌有协同作用。科里氏菌科 UCG-002 与糖酵解/糖异生呈显著负相关。罗塞尔氏菌与淀粉和蔗糖代谢的相关性最强。根据细菌功能预测和相关性分析，长期食用猪油或植物油可能会影响糖脂代谢，但猪油对人体健康和宿主健康的影响更大。
