Yi Lanlan, Li Zhipeng, Xu Hong, Shi Dejia, Huang Ying, Pan Hongbin, Zhao Yanguang, Zhao Hongye, Yang Minghua, Wei Hongjiang, Zhao Sumei
Yunnan Key Laboratory of Animal Nutrition and Feed Science, Yunnan Agricultural University, Kunming 650201, China.
Yunnan Province Key Laboratory for Porcine Gene Editing and Xenotransplantation, Yunnan Agricultural University, Kunming 650201, China.
Nutrients. 2025 Apr 22;17(9):1402. doi: 10.3390/nu17091402.
A high-fat diet leads to metabolic disturbances, which are important factors in the development of obesity. Gut microbial composition and diversity are altered by a high-fat diet. In general, a high-fat diet resulted in increased Firmicutes abundance and decreased alpha diversity. Bile acids (BAs) are involved in the digestion and absorption of fats in the small intestine and are also the metabolic substrates of microorganisms with bile salt hydrolase (BSH) activity. High-fat diets (HFDs) have been shown to alter gut microbiota composition and BA profiles in murine models. Similarly, probiotic supplementation reverses HFD-induced adverse effects. This review focuses on the energy composition characteristics of a high-fat diet and its effects on body weight, plasma lipid-related biochemical markers, changes in gut microbiome characteristics, and the important role of BAs. The regular mechanism by which a high-fat diet affects the intestinal microenvironment was attempted to be found.
高脂饮食会导致代谢紊乱，而代谢紊乱是肥胖症发展的重要因素。高脂饮食会改变肠道微生物的组成和多样性。一般来说，高脂饮食会导致厚壁菌门丰度增加，α多样性降低。胆汁酸（BAs）参与小肠中脂肪的消化和吸收，也是具有胆汁盐水解酶（BSH）活性的微生物的代谢底物。在小鼠模型中，高脂饮食（HFDs）已被证明会改变肠道微生物群组成和胆汁酸谱。同样，补充益生菌可逆转高脂饮食引起的不良反应。本综述重点关注高脂饮食的能量组成特征及其对体重、血浆脂质相关生化标志物、肠道微生物群特征变化以及胆汁酸的重要作用。试图找出高脂饮食影响肠道微环境的常规机制。
Am J Physiol Gastrointest Liver Physiol. 2021-12-1
Int J Mol Sci. 2025-6-27
Gut Microbes. 2025-12
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