Li Shuojohn, Alsaiqali Mahmoud, Narayanaswamy Meenakshi, McFarlane Isabel
Internal Medicine, State University of New York Downstate Health Sciences University, Brooklyn, USA.
Internal Medicine, State University of New York Downstate Medical Center, Brooklyn, USA.
Cureus. 2022 Sep 1;14(9):e28674. doi: 10.7759/cureus.28674. eCollection 2022 Sep.
Severe proteinuria and nephrotic syndrome are well documented causes or exacerbating factor of hypothyroidism. Less commonly known is that hypothyroidism, one of the most commonly encountered endocrinopathies, also has a profound effect on renal function and may lead to proteinuria. Here we report a case of female patient with hypothyroidism who presented with new onset severe proteinuria. Based on clinical data, we suspect the patient may have entered a vicious cycle of hypothyroidism and severe proteinuria where the two conditions worsen each other. Through literature review, we provide summaries of evidence supporting this bidirectional relationship between hypothyroidism and proteinuria, and emphasize on the importance of recognizing such association in clinical practice.
严重蛋白尿和肾病综合征是甲状腺功能减退症的充分记录的病因或加重因素。鲜为人知的是，甲状腺功能减退症作为最常见的内分泌疾病之一，也对肾功能有深远影响，并可能导致蛋白尿。在此，我们报告一例患有甲状腺功能减退症的女性患者，该患者出现新发的严重蛋白尿。根据临床资料，我们怀疑该患者可能进入了甲状腺功能减退症和严重蛋白尿的恶性循环，即这两种情况相互恶化。通过文献综述，我们总结了支持甲状腺功能减退症和蛋白尿之间这种双向关系的证据，并强调在临床实践中认识到这种关联的重要性。
