Engelhardt G
Arzneimittelforschung. 1987 May;37(5):519-23.
Various corticoid derivatives administered by inhalation or intraperitoneally were investigated for a preventive effect on the pulmonary oedema of the rat induced by the 30-min inhalation of 100-105 ppm NO2. After inhalational administration in the form of an aqueous aerosol, dexamethasone-21-isonicotinate showed a considerably greater efficacy than beclomethasone-17,21-dipropionate or dexamethasone-21-dihydrogen phosphate. With prophylactic intraperitoneal administration dexamethasone (free alcohol), dexamethasone-21-dihydrogen phosphate and 6 alpha-methylprednisolone-21-dihydrogen succinate had to be given in much higher doses than dexamethasone-21-isonicotinate to achieve the same effects on the toxic pulmonary oedema.
研究了通过吸入或腹腔注射给予的各种皮质类固醇衍生物对大鼠吸入100 - 105 ppm二氧化氮30分钟所致肺水肿的预防作用。以水性气雾剂形式吸入给药后，地塞米松-21-异烟酸酯的疗效明显高于倍氯米松-17,21-二丙酸酯或地塞米松-21-磷酸二氢盐。预防性腹腔注射时，地塞米松（游离醇）、地塞米松-21-磷酸二氢盐和6α-甲基泼尼松龙-21-琥珀酸二氢盐必须给予比地塞米松-21-异烟酸酯高得多的剂量才能对中毒性肺水肿产生相同的效果。
