Rao J, Das P K
Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan.
Malays J Pathol. 1994 Dec;16(2):165-6.
Healthy adult male albino rats were subjected to inhalation of increasing doses of detergent (dioctyl sodium sulfo-succinate) aerosol ranging from 100 mg to 500 mg. Administration of 500 mg of detergent aerosol resulted in peribronchial and focal alveolar oedema in 3 out of 5 animals. The lungs of control animals which were subjected to inhalation of vehicle aerosol (ethanol and saline) did not show any abnormality. It is possible that pulmonary oedema observed in detergent aerosol inhalation may be due to the action of detergents on the surfactant system of the lung.
将健康成年雄性白化大鼠暴露于吸入剂量递增的洗涤剂（磺基琥珀酸二辛酯钠）气雾剂中，剂量范围为100毫克至500毫克。吸入500毫克洗涤剂气雾剂后，5只动物中有3只出现支气管周围和局灶性肺泡水肿。吸入载体气雾剂（乙醇和盐水）的对照动物肺部未显示任何异常。吸入洗涤剂气雾剂时观察到的肺水肿可能是由于洗涤剂对肺表面活性物质系统的作用所致。
