Rshoud Firas Al, Omari Bayan Al, Qudsi Azmi, Salhiyeh Ala'a Abu
Department of Obstetrics and Gynaecology, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Prz Menopauzalny. 2022 Jun;21(2):106-110. doi: 10.5114/pm.2022.116478. Epub 2022 May 30.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder and is one of the most common causes of infertility. The study aimed to investigate the association between endometrial polyp and infertility in PCOS in a high-incidence region such as the Middle East. Also, to identify the most common risk factors for endometrial polyp(s) in PCOS patients with infertility.
We conducted a retrospective cohort study on a total of 250 patients with a confirmed diagnosis of a PCOS. Eighty patients out of the 250 were finally included in the study after a high suspicion of endometrial polyp by 2-D transvaginal ultrasound at the early follicular phase, and they underwent an office hysteroscopy at the late follicular phase after proper counselling.
Out of 80 patients enrolled in the study, 62 were confirmed to have endometrial polyp(s) by office hysteroscopy; 6 patients had a polypoid endometrium, 10 patients had an isolated increased endometrial thickness, and 2 patients had a small submucosal fibroid (less than 1.5 cm). The most observed co-factors in patients with PCOS and endometrial polyps are obesity, followed by oligomenorrhoea and amenorrhoea (hyperoestrogenic status).
Our study found that there is an association between PCOS with infertility and endometrial polyp(s). The most common associated factor is obesity, followed by oligomenorrhoea and amenorrhoea (hyperoestrogenic status). We hope that our study will raise global awareness about the unwanted effects of obesity in PCOS on general and reproductive health. A large study in the future is needed to confirm our results.
多囊卵巢综合征（PCOS）是最常见的内分泌紊乱疾病，也是不孕症最常见的病因之一。本研究旨在调查中东等高发地区PCOS患者中子宫内膜息肉与不孕症之间的关联。此外，确定PCOS不孕症患者子宫内膜息肉最常见的危险因素。
我们对总共250例确诊为PCOS的患者进行了一项回顾性队列研究。在卵泡早期经阴道二维超声高度怀疑子宫内膜息肉后，250例患者中的80例最终被纳入研究，并在适当咨询后于卵泡晚期接受了门诊宫腔镜检查。
在纳入研究的80例患者中，62例经门诊宫腔镜检查确诊有子宫内膜息肉；6例有息肉样子宫内膜，10例有单纯子宫内膜厚度增加，2例有小的黏膜下肌瘤（小于1.5 cm）。PCOS合并子宫内膜息肉患者中最常见的伴随因素是肥胖，其次是月经过少和闭经（高雌激素状态）。
我们的研究发现PCOS不孕症与子宫内膜息肉之间存在关联。最常见的相关因素是肥胖，其次是月经过少和闭经（高雌激素状态）。我们希望我们的研究能提高全球对PCOS中肥胖对一般健康和生殖健康产生不良影响的认识。未来需要进行大规模研究来证实我们的结果。
