Ulrich G
Arzneimittelforschung. 1987 May;37(5):541-5.
A double-blind cross-over comparison between the calcium antagonist nimodipine (Nimotop) and placebo with a group of 14 young, healthy volunteers showed the following: The effect of nimodipine on the EEG consists of changes in the anterior-posterior relations of absolute alpha-power which are considered to be an indicator of the vigilance level. This effect can only be demonstrated when the individual baseline (placebo-EEG) is taken into consideration. The group has been dichotomized into half-groups with higher and lower levels of vigilance. The half-group with higher levels of vigilance (n = 7) showed a decrease, the half-group with lower levels of vigilance (n = 7) showed an increase of vigilance under nimodipine. The decrease of the vigilance level was accompanied by an improvement of self-rated well-being, the increase with a deterioration. These results support earlier findings according to which nimodipine interindividually effects a stabilization of vigilance at a medium level.
一项针对14名年轻健康志愿者进行的钙拮抗剂尼莫地平（尼莫通）与安慰剂的双盲交叉比较显示如下：尼莫地平对脑电图的影响包括绝对α波功率前后关系的变化，这被认为是警觉水平的一个指标。只有考虑到个体基线（安慰剂脑电图）时，这种影响才能显现出来。该组被分为警觉水平较高和较低的两个半组。警觉水平较高的半组（n = 7）在服用尼莫地平时警觉性下降，警觉水平较低的半组（n = 7）在服用尼莫地平时警觉性增加。警觉水平的下降伴随着自我评定幸福感的改善，而警觉水平的增加则伴随着幸福感的恶化。这些结果支持了早期的研究结果，即尼莫地平在个体间能使警觉性稳定在中等水平。
