[A computer oculographic and electroencephalographic double-blind study including well-being for determining changed vigilance under therapy with tiapride].

Owing to its specific action on the dopaminergic neurons of the corpus striatum, which has been demonstrated in animal experiments. N-[2-(diethylamino)ethyl]-5-(methyl-sulfonyl)-o-anisamide (tiapride, Tiapridex) a recently developed drug from the family of the benzamides, appears to be particularly suited for the treatment of motor disorders resulting from extrapyramidal effects. In a double-blind study, the action of the drug on the vigilance of 16 normal subjects was compared with that of diazepam and a placebo. A minor reduction in vigilance was seen in the EOG and EEG following administration of 100 mg three times daily. However, this effect would not be expected to impair general performance or behaviour in traffic. With regard to self-assessment (existential orientation scale, list of complaints), no change was noted in male individuals receiving tiapride, while female test persons exhibited a slight tendency toward feeling low, though their mood remained above the limits of depression.