DNA binding studies on 1OH-pyrrolizino[1,2-b]quinolines.

1OH-Pyrrolizino [1,2-b]quinolines exhibited intercalation when tested by the following methods: effect of DNA on spectral properties, spectrophotometric titration, fluorescence enhancement of homidium bromide (ethidium bromide), thermal denaturation of DNA, effect on covalently closed circular double stranded PM-2 (Col E 1 plasmid) DNA. Some of the compounds showed antiproliferative activity in HeLa cells.