Saymazlar Dilek Damla, Kara Ozlem, Orhaner Betul Biner
Department of Pediatrics, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkiye.
Department of Pediatric Endocrinology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkiye.
North Clin Istanb. 2022 Jul 6;9(3):235-240. doi: 10.14744/nci.2021.15870. eCollection 2022.
Vitamin D deficiency is common in children. The effects of Vitamin D on bone health are well-known. However, its effect on glucose and lipid metabolism in obese children remains controversial. This study projected to evaluate the association between Vitamin D level and glucose, lipid, and bone metabolism parameters in obese children. In addition, the objective of the study was to determine the change in insulin resistance after Vitamin D replacement therapy in obese children with Vitamin D deficiency.
Hundred fifty children with obesity were included in our retrospective cross-sectional study. The patients were separated into two groups as the study group (serum 25(OH)D level <20 ng/ml) and the control group (serum 25(OH)D level ≥20 ng/ml). Physical examination, body fat mass, and laboratory findings of the two groups were compared. Moreover, patients in the study group were supplemented with Vitamin D 2000 IU/d for 24 weeks. Glucose, insulin levels were analyzed before and after treatment.
Body fat mass and percentage were evaluated as more raised in the study group than those in the control group. The study group had a higher level of insulin resistance. There was a significant loss in body weight of patients after treatment in the study group and insulin resistance of the study group decreased after Vitamin D3 treatment.
Considering the low side effects and affordability of Vitamin D, it would be a reasonable approach to identify serum Vitamin D levels in obese children and to administer a treatment to those with Vitamin D deficiency.
维生素D缺乏在儿童中很常见。维生素D对骨骼健康的影响是众所周知的。然而，其对肥胖儿童糖脂代谢的影响仍存在争议。本研究旨在评估肥胖儿童维生素D水平与糖、脂及骨代谢参数之间的关联。此外，该研究的目的是确定维生素D缺乏的肥胖儿童在进行维生素D替代治疗后胰岛素抵抗的变化。
150名肥胖儿童纳入我们的回顾性横断面研究。患者被分为两组，即研究组（血清25(OH)D水平<20 ng/ml）和对照组（血清25(OH)D水平≥20 ng/ml）。比较两组的体格检查、体脂质量和实验室检查结果。此外，研究组患者补充维生素D 2000 IU/d，持续24周。治疗前后分析血糖、胰岛素水平。
研究组的体脂质量和百分比评估结果高于对照组。研究组的胰岛素抵抗水平更高。研究组患者治疗后体重显著减轻，维生素D3治疗后研究组的胰岛素抵抗降低。
考虑到维生素D的副作用低且价格可承受，检测肥胖儿童的血清维生素D水平并对维生素D缺乏者进行治疗将是一种合理的方法。
