Uppal Deepak Kumar, Madan Renu, Peters Nitin J, Bal Amanjit, Ballari Nagarjun, Goyal Shikha, Khosla Divya
Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Department of Pediatric Surgery, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Radiat Oncol J. 2022 Sep;40(3):208-212. doi: 10.3857/roj.2021.00500. Epub 2022 Sep 29.
Mucoepidermoid carcinoma (MEC) is most common malignancy of minor salivary glands in adults. Pulmonary MEC is extremely uncommon comprising of only 0.1%-0.2% of the primary lung malignancies and <1% of primary bronchial tumors. It is even rarer in children and literature limited to few case reports only. Here we present a case report of a 9-year-old boy diagnosed with primary MEC of trachea along with review of the literature. A 9-year-old male child presented with complaint of dry cough for two years which was later associated with shortness of breath after one year. Bronchoscopic examination revealed a growth arising from right lateral wall of carina occluding 50% of the lumen and detailed histopathological examination revealed it to be a MEC of the trachea. Patient underwent local excision of the tumor with primary anastomosis. In view of positive margins adjuvant radiotherapy of 60 Gy in 30 fractions were given to the tumor bed. Patient tolerated the treatment well and is disease free at 6 months follow-up. Experience with MEC of the trachea in children is limited and optimal treatment protocols have not been defined, with current treatment mainly extrapolated from MEC of the salivary glands.
黏液表皮样癌（MEC）是成人小涎腺最常见的恶性肿瘤。肺黏液表皮样癌极为罕见，仅占原发性肺恶性肿瘤的0.1%-0.2%，占原发性支气管肿瘤的比例不到1%。在儿童中更为罕见，文献报道仅限于少数病例。在此，我们报告一例9岁男孩诊断为原发性气管黏液表皮样癌的病例，并对相关文献进行回顾。一名9岁男童主诉干咳两年，一年后出现气短。支气管镜检查发现隆突右侧壁有一肿物，阻塞管腔50%，详细的组织病理学检查显示为气管黏液表皮样癌。患者接受了肿瘤局部切除及一期吻合术。鉴于切缘阳性，对瘤床给予60 Gy分30次的辅助放疗。患者对治疗耐受性良好，随访6个月无疾病复发。儿童气管黏液表皮样癌的治疗经验有限，尚未确定最佳治疗方案，目前的治疗主要是借鉴涎腺黏液表皮样癌的治疗方法。
