He Yuqin, Li Han, Wang Kai, Wang Jian, Zhu Yiming, Ni Song, Liu Shaoyan
Department of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Head Neck. 2023 Jan;45(1):85-94. doi: 10.1002/hed.27208. Epub 2022 Oct 6.
It is unclear whether differences in clinical presentation and/or prognosis exist between prepubertal papillary thyroid cancer (PTC) and pubertal PTC. At present, there is a lack of definition for the appropriate cutoff age to define prepubertal PTC.
This study retrospectively reviewed 227 pediatric PTC patients (aged ≤18 years) who underwent initial surgery from March 2000 to December 2018. The median duration of follow-up was 85 months (range, 8-258).
The age range was basically linearly related to multiple risk factors, such as T3-T4 disease, distant metastasis. Age (p = 0.032) was an independent risk factor for recurrence and persistent disease. Patients aged <14 years had obviously higher rates of extensive disease. The 10-year disease-free survival (DFS) rate of patients aged <14 years was 59.5% and that of patients aged ≥14 years was 82.6% (p = 0.004).
Fourteen years of age may be an appropriate cutoff to differentiate prepubertal PTC from pubertal PTC.
青春期前乳头状甲状腺癌（PTC）与青春期PTC在临床表现和/或预后方面是否存在差异尚不清楚。目前，对于定义青春期前PTC的合适截止年龄缺乏明确界定。
本研究回顾性分析了2000年3月至2018年12月期间接受初次手术的227例儿科PTC患者（年龄≤18岁）。中位随访时间为85个月（范围8 - 258个月）。
年龄范围与多种危险因素基本呈线性相关，如T3 - T4期疾病、远处转移。年龄（p = 0.032）是复发和疾病持续存在的独立危险因素。年龄<14岁的患者广泛疾病发生率明显更高。年龄<14岁患者的10年无病生存率（DFS）为59.5%，年龄≥14岁患者为82.6%（p = 0.004）。
14岁可能是区分青春期前PTC与青春期PTC的合适截止年龄。
