Kriete A, Schäffer R, Harms H, Aus H M
Anal Quant Cytol Histol. 1987 Jun;9(3):268-72.
Nuclei of the cells from the thyroid gland were analyzed in a transmission electron microscope by direct TV scanning and on-line image processing. The method uses the advantages of a visual-perception model to detect structures in noisy and low-contrast images. The features analyzed include area, a form factor and texture parameters from the second derivative stage. Three tumor-free thyroid tissues, three follicular adenomas, three follicular carcinomas and three papillary carcinomas were studied. The computer-aided cytophotometric method showed that the most significant differences were the statistics of the chromatin texture features of homogeneity and regularity. These findings document the possibility of an automated differentiation of tumors at the ultrastructural level.
通过直接电视扫描和在线图像处理，在透射电子显微镜下对甲状腺细胞的细胞核进行了分析。该方法利用视觉感知模型的优势来检测噪声和低对比度图像中的结构。分析的特征包括面积、形状因子和二阶导数阶段的纹理参数。研究了三个无肿瘤的甲状腺组织、三个滤泡性腺瘤、三个滤泡性癌和三个乳头状癌。计算机辅助细胞光度法显示，最显著的差异是染色质纹理特征的均匀性和规则性统计。这些发现证明了在超微结构水平上自动区分肿瘤的可能性。
