Kriete A, Schäffer R, Harms H, Aus H M
J Cancer Res Clin Oncol. 1985;109(3):252-6. doi: 10.1007/BF00390365.
This study of 14 follicular adenomas, 10 papillary carcinomas and 11 follicular carcinomas of the human thyroid gland demonstrates the possibility of a cytological tumor classification using digital picture processing. Routinely prepared, HE-stained imprints of surgical specimens were scanned under a light microscope at high resolution with a colour TV camera. The cell nuclei were segmented and analysed with an image processing system. The computer-aided cytophotometric methods detected the most significant differences in the chromatin texture with a criteria variance of texture line distances and texture points per texture knots. Using these criteria benign and malignant tumor types could be successfully differentiated.
这项对14例人甲状腺滤泡性腺瘤、10例乳头状癌和11例滤泡状癌的研究表明，利用数字图像处理进行肿瘤细胞学分类是可行的。手术标本常规制备的苏木精-伊红（HE）染色印片在光学显微镜下用彩色电视摄像机进行高分辨率扫描。用图像处理系统对细胞核进行分割和分析。计算机辅助细胞光度测定法通过纹理线距离和每个纹理节的纹理点的标准方差检测染色质纹理中最显著的差异。利用这些标准能够成功区分良性和恶性肿瘤类型。
