Wei Zhen-Zhen, Zhou Ti-Qiang, Xia Zi-Ming, Liu Si-Fan, Li Min, Zhang Guang-Jie, Tian Ying, Li Bin, Wang Lin
Faculty of Environment and Life, Beijing University of Technology, Beijing, China.
Department of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing, China.
Nat Prod Res. 2023 Aug-Sep;37(16):2688-2696. doi: 10.1080/14786419.2022.2130307. Epub 2022 Oct 6.
Phytochemical investigation of the seeds of led to the isolation of four organosulfur compounds. There were two new compounds, 10-methylsulfinyl-decanamide () and 11-methylsulfinyl-undecanamide (), along with two known compounds (-), which all have a sulfoxide group and an amide or a nitrile group. Their chemical structures were elucidated by analysing UV, IR, ESI-MS and NMR spectroscopy. In addition, compounds - were evaluated for their anti-inflammatory activities by using LPS-induced RAW 264.7 cells. Compounds - exhibited potential anti-inflammatory activities on NO release characterised by decreasing the mRNA expression levels of inducible NO synthase (iNOS), cytokines cyclooxygenase-2 (COX-2) and interleukin 6 (IL-6).
对[植物名称]种子进行植物化学研究，从中分离出四种有机硫化合物。有两种新化合物，10-甲基亚磺酰基癸酰胺（[化合物1名称]）和11-甲基亚磺酰基十一酰胺（[化合物2名称]），以及两种已知化合物（[已知化合物1名称]）和（[已知化合物2名称]），它们均含有一个亚砜基团和一个酰胺或腈基。通过分析紫外光谱、红外光谱、电喷雾电离质谱和核磁共振光谱对其化学结构进行了阐明。此外，利用脂多糖诱导的RAW 264.7细胞对化合物（[已知化合物1名称]）和（[已知化合物2名称]）的抗炎活性进行了评估。化合物（[已知化合物1名称]）和（[已知化合物2名称]）对一氧化氮释放表现出潜在的抗炎活性，其特征在于降低诱导型一氧化氮合酶（iNOS）、细胞因子环氧化酶-2（COX-2）和白细胞介素6（IL-6）的mRNA表达水平。
