荠菜中的酚苷类成分及其抗炎活性
Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity.
作者信息
Cha Joon Min, Suh Won Se, Lee Tae Hyun, Subedi Lalita, Kim Sun Yeou, Lee Kang Ro
机构信息
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Gachon Institute of Pharmaceutical Science, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Korea.
出版信息
Molecules. 2017 Jun 20;22(6):1023. doi: 10.3390/molecules22061023.
A new sesquilignan glycoside , together with seven known phenolic glycosides - were isolated from the aerial parts of The chemical structure of the new compound was elucidated by extensive nuclear magnetic resonance (NMR) data (¹H- and C-NMR, ¹H-¹H correlation spectroscopy (¹H-¹H COSY), heteronuclear single-quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear overhauser effect spectroscopy (NOESY)) and HR-FABMS analysis. The anti-inflammatory effects of - were evaluated in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Compounds and exhibited moderate inhibitory effects on nitric oxide production in LPS-activated BV-2 cells, with IC values of 17.80 and 27.91 µM, respectively.
从[植物名称]的地上部分分离出一种新的倍半木脂素糖苷以及七种已知的酚类糖苷。通过广泛的核磁共振（NMR）数据（¹H-和¹³C-NMR、¹H-¹H相关光谱（¹H-¹H COSY）、异核单量子相关（HSQC）、异核多键相关（HMBC）和核Overhauser效应光谱（NOESY））以及高分辨快原子轰击质谱（HR-FABMS）分析阐明了新化合物的化学结构。在脂多糖（LPS）刺激的小鼠小胶质细胞BV-2细胞中评估了[化合物名称]的抗炎作用。化合物[具体化合物编号1]和[具体化合物编号2]对LPS激活的BV-2细胞中一氧化氮的产生表现出中等程度的抑制作用，IC₅₀值分别为17.80和27.91 μM。
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