1 Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
2 Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
J Altern Complement Med. 2018 Jul;24(7):694-700. doi: 10.1089/acm.2017.0267. Epub 2018 Mar 20.
Heavy menstrual bleeding (HMB) is one of the leading causes of low quality of life and iron deficiency anemia in women. This study aimed to determine the effect of hydroalcoholic extracts of Capsella bursa-pastoris on HMB.
This study is a triple-blinded, randomized clinical trial.
The study was conducted in gynecology clinics affiliated to Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Our patients affected to a complaint of HMB. After obtaining a complete medical history of the women and filling out the demographic forms, the participants were assigned randomly into the experimental (n = 42) and control groups (n = 42).
The eligible participants were given a pictorial blood loss assessment chart (PBLAC) to confirm HMB during the menstrual cycle. The experimental group received two capsules of mefenamic acid (500 mg) every 8 h and two Capsella bursa-pastoris capsules every 12 h. The intervention started from the first day of menstruation to the end of this period up to 7 days for two consecutive cycles. In the control group, the patients received mefenamic acid and placebo instead of Capsella bursa-pastoris capsules.
The PBLAC score and number of bleeding days, incidence of any possible problems, as well as participant satisfaction were measured. The data were analyzed using t-test, Chi-square, repeated-measures ANOVA, and ANCOVA tests in PASW Statistics ver. 18.
After the intervention, there was observed significant decrease in the amount of menstrual bleeding in both groups. However, the mean decrease in the amount of bleeding was significantly more in the Capsella bursa-pastoris group (p < 0/001).
Compared with control group, hydroalcoholic extracts of Capsella bursa-pastoris capsule appeared to be effective in reducing menstrual bleeding in this study. Further research regarding the efficacy and safety of Capsella bursa-pastoris is required.
月经过多（HMB）是导致女性生活质量低下和缺铁性贫血的主要原因之一。本研究旨在确定荠菜水醇提取物对 HMB 的影响。
这是一项三盲、随机临床试验。
本研究在伊朗德黑兰沙希德·贝赫什提大学医学科学附属的妇科诊所进行。
我们的患者因 HMB 就诊。在获得女性完整病史并填写人口统计学表格后，将参与者随机分为实验组（n=42）和对照组（n=42）。
符合条件的参与者使用图片出血评估图表（PBLAC）在月经周期内确认 HMB。实验组每 8 小时服用 2 粒甲芬那酸（500mg），每 12 小时服用 2 粒荠菜胶囊。干预从月经第一天开始，持续到本次周期结束，连续两个周期共 7 天。在对照组中，患者服用甲芬那酸和安慰剂代替荠菜胶囊。
使用 PBLAC 评分和出血天数、任何可能问题的发生率以及参与者满意度来衡量。使用 PASW Statistics ver. 18 中的 t 检验、卡方检验、重复测量方差分析和协方差分析对数据进行分析。
干预后，两组的月经量均明显减少。然而，荠菜组的出血量减少幅度明显更大（p<0.001）。
与对照组相比，在本研究中，荠菜水醇提取物胶囊似乎能有效减少月经出血。需要进一步研究荠菜的疗效和安全性。
