同伴支持的轻度认知障碍患者运动干预：一项等候名单随机对照试验（大脑活力增强试验）

Peer-supported exercise intervention for persons with mild cognitive impairment: a waitlist randomised controlled trial (the BRAin Vitality Enhancement trial).

作者信息

Li Polly W C, Yu Doris S F, Siu Parco M, Wong Schwinger C K, Chan Bernice S

机构信息

School of Nursing, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.

School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.

出版信息

Age Ageing. 2022 Oct 6;51(10). doi: 10.1093/ageing/afac213.

DOI:10.1093/ageing/afac213

PMID:36201330

Abstract

BACKGROUND

motivating older people with cognitive impairment to remain physically active is challenging.

OBJECTIVE

this study aimed to examine the effects of a peer-supported exercise intervention on the cognitive function and health-related quality of life (HRQoL) of persons with mild cognitive impairment (MCI).

DESIGN

a two-arm randomised controlled trial.

SETTING AND PARTICIPANTS

community-dwelling persons with MCI were recruited from community centres for older adults in Hong Kong.

METHODS

participants randomised to the intervention group received an 8-week group-based peer-supported multicomponent exercise intervention, while the waitlist control group received usual care. A battery of neuropsychological tests and the Short Form-36 were administered at baseline, immediately post-intervention and 3 months post-intervention.

RESULTS

two hundred and twenty-nine participants were randomised to the intervention (n = 116) or control (n = 113) group. Compared with the control group, participants in the intervention group showed significantly greater improvements in processing speed and attention measured by the Colour Trails Test 1 (β = 7.213, 95% confidence interval [CI] = 2.870-11.557, P = 0.001) and working memory measured by the Digit Span Backward Test (β = 0.540, 95% CI = 0.199-0.881, P = 0.002) immediately post-intervention. The effects were sustained at 3 months post-intervention. Similarly, significantly greater improvements in sequencing and mental flexibility measured by the Colour Trails Test 2 were observed in the intervention group 3 months post-intervention (β = 6.979, 95% CI = 3.375-10.584, P < 0.001). Changes in global cognition, short-term memory and HRQoL were not significant.

CONCLUSION

the peer-supported exercise intervention was effective at sustaining improvements in executive function, attention and working memory in persons with MCI.

摘要

背景

激励认知障碍的老年人保持身体活动具有挑战性。

目的

本研究旨在探讨同伴支持的运动干预对轻度认知障碍（MCI）患者认知功能和健康相关生活质量（HRQoL）的影响。

设计

双臂随机对照试验。

设置和参与者

从香港老年人社区中心招募社区居住的MCI患者。

方法

随机分配到干预组的参与者接受为期8周的基于小组的同伴支持多组分运动干预，而等待名单对照组接受常规护理。在基线、干预后立即和干预后3个月进行一系列神经心理学测试和简短健康调查问卷（Short Form-36）。

结果

229名参与者被随机分配到干预组（n = 116）或对照组（n = 113）。与对照组相比，干预组参与者在干预后立即通过色词测验1（Colour Trails Test 1）测量的加工速度和注意力（β = 7.213，95%置信区间[CI] = 2.870 - 11.557，P = 0.001）以及通过数字广度倒背测验（Digit Span Backward Test）测量的工作记忆（β = 0.540，95% CI = 0.199 - 0.881，P = 0.002）方面有显著更大的改善。这些效果在干预后3个月持续存在。同样，干预组在干预后3个月通过色词测验2测量的序列能力和心理灵活性方面有显著更大的改善（β = 6.979，95% CI = 3.375 - 10.584，P < 0.001）。整体认知、短期记忆和HRQoL的变化不显著。