质子泵抑制剂反应性和非反应性嗜酸性食管炎的重叠转录谱。
Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis.
机构信息
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Clin Transl Gastroenterol. 2022 Nov 1;13(11):e00540. doi: 10.14309/ctg.0000000000000540.
Abstract
INTRODUCTION
We compared esophageal mucosal gene transcript expression in proton pump inhibitor (PPI) responsive (PPI-R) eosinophilic esophagitis (EoE), PPI nonresponsive (PPI-NR) EoE, and healthy controls.
METHODS
Transcript expression in midesophagus biopsies was determined using NanoString and a custom panel of EoE-specific genes. The top upregulated and downregulated genes with ≥2-fold difference in expression and statistically significant ( P < 0.05) were identified.
RESULTS
Nearly all the top upregulated (17 of 20) and downregulated (5 of 5) genes in EoE, compared with healthy controls, were shared between the PPI-R and PPI-NR groups.
DISCUSSION
Esophageal mucosal transcript expressions are remarkably similar in PPI-R EoE and PPI-NR EoE compared with healthy controls.
摘要
简介
我们比较了质子泵抑制剂（PPI）反应性（PPI-R）嗜酸性食管炎（EoE）、PPI 无反应性（PPI-NR）EoE 和健康对照组的食管黏膜基因转录表达。
方法
使用 NanoString 和 EoE 特异性基因的定制面板测定中食管活检的转录表达。鉴定出表达差异≥2 倍且具有统计学意义（P < 0.05）的前上调和下调基因。
结果
与健康对照组相比，EoE 中几乎所有上调（20 个中的 17 个）和下调（5 个中的 5 个）的基因在 PPI-R 和 PPI-NR 组中都是共有的。
讨论
与健康对照组相比，PPI-R EoE 和 PPI-NR EoE 的食管黏膜转录表达非常相似。
相似文献
1
Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis.质子泵抑制剂反应性和非反应性嗜酸性食管炎的重叠转录谱。
Clin Transl Gastroenterol. 2022 Nov 1;13(11):e00540. doi: 10.14309/ctg.0000000000000540.
2
CYP2C19 and STAT6 Variants Influence the Outcome of Proton Pump Inhibitor Therapy in Pediatric Eosinophilic Esophagitis.CYP2C19 和 STAT6 变体影响质子泵抑制剂治疗小儿嗜酸性粒细胞性食管炎的疗效。
J Pediatr Gastroenterol Nutr. 2019 Nov;69(5):581-587. doi: 10.1097/MPG.0000000000002480.
3
Children with eosinophilic esophagitis non-responsive to combination therapy have distinct esophageal transcriptomic and microbiome profile.嗜酸细胞性食管炎患儿对联合治疗无反应，其食管转录组和微生物组特征明显不同。
Allergy. 2024 Oct;79(10):2798-2811. doi: 10.1111/all.16208. Epub 2024 Jul 12.
4
Proton pump inhibitors partially restore mucosal integrity in patients with proton pump inhibitor-responsive esophageal eosinophilia but not eosinophilic esophagitis.质子泵抑制剂可部分恢复质子泵抑制剂反应性食管嗜酸性粒细胞增多症患者的黏膜完整性，但不能恢复嗜酸性粒细胞性食管炎。
Clin Gastroenterol Hepatol. 2014 Nov;12(11):1815-23.e2. doi: 10.1016/j.cgh.2014.02.037. Epub 2014 Mar 19.
5
Assessment of the clinical and allergy profiles of PPI responsive and non-responsive eosinophilic esophagitis.质子泵抑制剂应答和非应答嗜酸性粒细胞性食管炎的临床和过敏特征评估。
Dis Esophagus. 2023 Jul 3;36(7). doi: 10.1093/dote/doac098.
6
Increased expression of proton pump and allergic inflammation genes predicts PPI failure in pediatric eosinophilic esophagitis.质子泵和过敏性炎症基因表达增加预示着儿童嗜酸性粒细胞性食管炎对质子泵抑制剂治疗无效。
Dis Esophagus. 2025 Jan 7;38(1). doi: 10.1093/dote/doae071.
7
Allergic phenotype identified on allergen testing is associated with proton pump inhibitor nonresponse in eosinophilic esophagitis.在变应原测试中确定的过敏表型与嗜酸性粒细胞性食管炎中质子泵抑制剂无应答相关。
J Gastroenterol Hepatol. 2024 Apr;39(4):701-707. doi: 10.1111/jgh.16469. Epub 2024 Jan 7.
8
Similarities and differences among eosinophilic esophagitis, proton-pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: comparisons of clinical, endoscopic, and histopathological findings in Japanese patients.嗜酸性粒细胞性食管炎、质子泵抑制剂反应性食管嗜酸性粒细胞增多症和反流性食管炎的异同：日本患者的临床、内镜和组织病理学表现比较。
J Gastroenterol. 2017 Feb;52(2):203-210. doi: 10.1007/s00535-016-1213-1. Epub 2016 Apr 23.
9
Immunohistochemical expression of filaggrin is decreased in proton pump inhibitor non-responders compared with proton pump inhibitor responders of eosinophilic esophagitis.与质子泵抑制剂治疗反应者相比，质子泵抑制剂无应答者的嗜酸性食管炎中丝聚合蛋白的免疫组织化学表达减少。
Esophagus. 2021 Apr;18(2):362-371. doi: 10.1007/s10388-020-00781-2. Epub 2020 Sep 9.
10
Esophageal eosinophilic infiltration responds to proton pump inhibition in most adults.大多数成年人的食管嗜酸性粒细胞浸润对质子泵抑制剂有反应。
Clin Gastroenterol Hepatol. 2011 Feb;9(2):110-7. doi: 10.1016/j.cgh.2010.09.019. Epub 2010 Oct 1.
引用本文的文献
1
Distribution of Esophageal Eosinophilia as a Predictor of Proton Pump Inhibitor Response in Eosinophilic Esophagitis.食管嗜酸性粒细胞增多症的分布作为嗜酸性粒细胞性食管炎中质子泵抑制剂反应的预测指标
Clin Gastroenterol Hepatol. 2025 Jul 16. doi: 10.1016/j.cgh.2025.06.032.
2
Comparative Assessment of Esophageal Proteomics in Eosinophilic Esophagitis Using SOMAscan.使用SOMAscan对嗜酸性食管炎患者的食管蛋白质组学进行比较评估。
Gastroenterology. 2024 Oct;167(5):1022-1025.e3. doi: 10.1053/j.gastro.2024.05.022. Epub 2024 May 28.
3
Proton-Pump Inhibitors in Eosinophilic Esophagitis: A Review Focused on the Role of Pharmacogenetics.质子泵抑制剂在嗜酸性食管炎中的应用：聚焦药物遗传学作用的综述
Pharmaceutics. 2024 Apr 2;16(4):487. doi: 10.3390/pharmaceutics16040487.
4
Allergic phenotype identified on allergen testing is associated with proton pump inhibitor nonresponse in eosinophilic esophagitis.在变应原测试中确定的过敏表型与嗜酸性粒细胞性食管炎中质子泵抑制剂无应答相关。
J Gastroenterol Hepatol. 2024 Apr;39(4):701-707. doi: 10.1111/jgh.16469. Epub 2024 Jan 7.
5
Relationship Between Esophageal Disease and Pulmonary Fibrosis.食管疾病与肺纤维化的关系。
Dig Dis Sci. 2023 Apr;68(4):1096-1105. doi: 10.1007/s10620-023-07908-2. Epub 2023 Mar 14.
本文引用的文献
1
Eosinophilic Esophagitis: A Review.嗜酸性粒细胞性食管炎：综述。
JAMA. 2021 Oct 5;326(13):1310-1318. doi: 10.1001/jama.2021.14920.
2
AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters Clinical Guidelines for the Management of Eosinophilic Esophagitis.美国胃肠病学会与过敏免疫实践参数联合工作组关于嗜酸性食管炎管理的临床指南。
Gastroenterology. 2020 May;158(6):1776-1786. doi: 10.1053/j.gastro.2020.02.038.
3
An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning.用于嗜酸性粒细胞性食管炎中 mRNA 模式分类的算法：机器学习的整合。
J Allergy Clin Immunol. 2018 Apr;141(4):1354-1364.e9. doi: 10.1016/j.jaci.2017.11.027. Epub 2017 Dec 19.
4
Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis.质子泵抑制剂反应性食管嗜酸性粒细胞增多症：一种对当前嗜酸性粒细胞性食管炎诊断标准构成挑战的病症。
Gut. 2016 Mar;65(3):524-31. doi: 10.1136/gutjnl-2015-310991. Epub 2015 Dec 18.
5
Efficacy of Proton Pump Inhibitor Drugs for Inducing Clinical and Histologic Remission in Patients With Symptomatic Esophageal Eosinophilia: A Systematic Review and Meta-Analysis.质子泵抑制剂药物治疗有症状性食管嗜酸性粒细胞增多症患者的临床和组织学缓解的疗效：系统评价和荟萃分析。
Clin Gastroenterol Hepatol. 2016 Jan;14(1):13-22.e1. doi: 10.1016/j.cgh.2015.07.041. Epub 2015 Aug 3.
6
Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation.质子泵抑制剂反应性食管嗜酸性粒细胞增多症的转录组分析揭示了质子泵抑制剂可逆转的过敏性炎症。
J Allergy Clin Immunol. 2015 Jan;135(1):187-97. doi: 10.1016/j.jaci.2014.08.043. Epub 2014 Oct 19.
7
Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner.嗜酸粒细胞性食管炎的诊断延迟会使狭窄形成的风险呈时间依赖性增加。
Gastroenterology. 2013 Dec;145(6):1230-6.e1-2. doi: 10.1053/j.gastro.2013.08.015. Epub 2013 Aug 13.
8
Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells.奥美拉唑阻断 STAT6 与嗜酸性粒细胞性食管炎细胞中 eotaxin-3 启动子的结合。
PLoS One. 2012;7(11):e50037. doi: 10.1371/journal.pone.0050037. Epub 2012 Nov 21.
9
Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD.奥美拉唑可抑制嗜酸粒细胞性食管炎和 GORD 患者食管鳞状细胞表达嗜酸性粒细胞趋化因子-3。
Gut. 2013 Jun;62(6):824-32. doi: 10.1136/gutjnl-2012-302250. Epub 2012 May 12.
Zotero 插件