Gentile Pietro, Cervelli Valerio
Plastic and Reconstructive Surgery, Department of Surgical Science, Medical School, "Tor Vergata" University, Rome 00133, Italy.
Academy of International Regenerative Medicine & Surgery Societies (AIRMESS), 1201 Geneva, Switzerland.
J Craniofac Surg. 2022 Oct 1;33(7):2035-2040. doi: 10.1097/SCS.0000000000008494. Epub 2022 Feb 2.
The objective of this study was to perform a systematic review of the literature to assess the clinical outcomes and safety profile of autologous cartilage grafts (A-CGs) in nasal tip remodeling (NTR).
The protocol was developed following the Preferred Reporting for Items for Systematic Reviews and Meta-Analyses-Protocols guidelines. A multistep search of the PubMed, MEDLINE, Embase, Scopus database, and Cochrane databases has been performed to identify papers on A-CGs use in NTR. Of the 253 articles initially identified, only 39 articles providing either retrospective (n = 35) or prospective (n = 4) data about outcomes, descriptions, and complications of the A-CGs use in NTR were selected. Of these, 3 articles focused on alloplastic grafts were excluded.
The nasal septum, concha, and ribs have been the main donor sites to build A-CGs to be used in NTR. Septal cartilage turned out to a specific and versatile, useful for many types of grafts tools, presenting a low rate of resorption, extrusion, and warping. Auricular concha cartilage has been used to correct both the internal and external nasal valve collapse, whereas rib chondral grafts have been used to improve the structural support when septal cartilage was not available. Crushed cartilage, minced cartilage, and diced cartilage have been used in noses with thinner soft tissues.
Eighty percent of the analyzed studies focused on the description of the adopted surgical technique and A-CGs procedures of preparation, displaying encouraging aesthetic and functional outcomes with generally low levels of complications. Collected data confirmed the safety and efficacy of A-CGs-related interventions in NTR without major side effects.
本研究的目的是对文献进行系统回顾,以评估自体软骨移植(A-CGs)在鼻尖重塑(NTR)中的临床结果和安全性。
该方案是根据系统评价和Meta分析方案的首选报告指南制定的。对PubMed、MEDLINE、Embase、Scopus数据库和Cochrane数据库进行了多步骤检索,以确定关于A-CGs在NTR中应用的论文。在最初确定的253篇文章中,仅选择了39篇提供关于A-CGs在NTR中应用的结果、描述和并发症的回顾性(n = 35)或前瞻性(n = 4)数据的文章。其中,3篇关注异体移植的文章被排除。
鼻中隔、耳甲和肋软骨是构建用于NTR的A-CGs的主要供体部位。鼻中隔软骨是一种特殊且通用的材料,可用于多种移植工具,吸收率、挤出率和翘曲率较低。耳甲软骨已被用于纠正鼻内和鼻外瓣膜塌陷,而肋软骨移植则在鼻中隔软骨不可用时用于改善结构支撑。粉碎软骨、切碎软骨和切块软骨已被用于软组织较薄的鼻子。
80%的分析研究集中在对所采用的手术技术和A-CGs制备过程的描述上,显示出令人鼓舞的美学和功能结果,并发症发生率普遍较低。收集的数据证实了A-CGs相关干预在NTR中的安全性和有效性,且无重大副作用。