副肿瘤性神经系统综合征更新诊断标准的实际应用
Real-world application of the updated diagnostic criteria for paraneoplastic neurological syndromes.
作者信息
Campetella Lucia, Papi Claudia, Sabatelli Eleonora, Marini Sofia, Iorio Raffaele
机构信息
Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, Italy.
Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, Italy; Institute of Neurology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.
出版信息
J Neuroimmunol. 2022 Nov 15;372:577972. doi: 10.1016/j.jneuroim.2022.577972. Epub 2022 Sep 22.
Following recent discoveries, diagnostic criteria for paraneoplastic neurological syndromes (PNS) have been recently updated. However, how the criteria impact PNS diagnosis is still unclear. We retrospectively applied the previously existing 2004 criteria (2004-c) and the updated 2021 diagnostic criteria (2021-c) to 74 patients with suspect PNS. The 2021 criteria were highly sensitive (88%) and specific (80%). There was good concordance between the definite PNS group (2004-c) and the definite plus probable PNS group (2021-c). The inter-rater reliability for the 2021-c was excellent. The application of the 2021 criteria improves the diagnosis of patients with PNS.
随着近期的发现，副肿瘤性神经系统综合征（PNS）的诊断标准最近已更新。然而，这些标准如何影响PNS的诊断仍不清楚。我们对74例疑似PNS患者回顾性应用了先前存在的2004年标准（2004-c）和更新后的2021年诊断标准（2021-c）。2021年标准具有高度敏感性（88%）和特异性（80%）。确诊PNS组（2004-c）与确诊加可能PNS组（2021-c）之间具有良好的一致性。2021-c的评分者间信度极佳。2021年标准的应用改善了PNS患者的诊断。
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