Peking University HuiLongGuan Clinical Medical School, Beijing HuiLongGuan Hospital, Beijing, China.
Department of Psychiatry, Shandong Mental Health Center, Shandong University, Jinan, China.
Asian J Psychiatr. 2022 Nov;77:103267. doi: 10.1016/j.ajp.2022.103267. Epub 2022 Sep 27.
The relationship between tobacco smoke and schizophrenia (SZ) is well established. Smoking is hypothesized to alleviate symptoms and reduce the adverse effects of antipsychotic medications in patients with SZ. However, the underlying biological mechanisms by which smoke improves symptoms in SZ remain unclear. The aim of this study was to investigate the effect of smoking on clinical symptoms and antioxidant enzyme activity after risperidone treatment in a 12-week prospective cohort study of drug-naïve first-episode (DNFE) SZ patients. Two hundred and fifteen DNFE patients were recruited and received 12 weeks of risperidone monotherapy. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of patient's symptoms at baseline and post-treatment. Plasma GPx activity was also measured at baseline and at the end of 12 weeks. Smokers showed greater improvement in negative symptoms relative to nonsmokers with DNFE SZ. In addition, repeated ANCOVA analysis showed no significant interaction of time and group on GPx activity. Improvement in negative symptoms was not associated with changes in GPx activity. However, in nonsmokers, increased GPx activity was correlated with improvement in positive symptoms.
吸烟与精神分裂症（SZ）之间的关系已得到充分证实。吸烟被假设可以缓解精神分裂症患者的症状，并减轻抗精神病药物的不良反应。然而，烟雾改善 SZ 症状的潜在生物学机制仍不清楚。本研究旨在通过前瞻性队列研究，调查吸烟对未经药物治疗的首发精神分裂症（DNFE）患者接受利培酮治疗 12 周后的临床症状和抗氧化酶活性的影响。共招募了 215 名 DNFE 患者，接受利培酮单药治疗 12 周。使用阳性和阴性综合征量表（PANSS）评估患者在基线和治疗后的症状严重程度。还在基线和 12 周结束时测量了血浆 GPx 活性。与 DNFE SZ 的非吸烟者相比，吸烟者的阴性症状改善更为明显。此外，重复方差分析显示，时间和组之间在 GPx 活性上没有显著的交互作用。阴性症状的改善与 GPx 活性的变化无关。然而，在非吸烟者中，GPx 活性的增加与阳性症状的改善相关。
