Gao Zhiyong, Xiu Meihong, Liu Jiahong, Wu Fengchun, Zhang Xiangyang
The Affiliated Kangning Hospital of Wenzhou Medical University Zhejiang Provincial Clinical Research Center for Mental Disorder, Wenzhou, China.
Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China.
Curr Neuropharmacol. 2024;22(10):1733-1741. doi: 10.2174/1570159X22666231019105328.
It has been hypothesized that smoking is associated with the severity of negative symptoms. Until now, no studies have investigated whether the impact of smoking on negative symptoms is dependent on antioxidants. This study was designed to evaluate the effect of smoking on therapeutic response and total antioxidants capacity (TAOC) in antipsychotic-naïve first-episode (ANFE) patients.
The severity of the patient's symptoms was assessed using the Positive and Negative Syndrome Scale (PANSS). A total of 237 ANFE patients were recruited and treated with risperidone (oral tablets, 4-6 mg/day twice a day) for 12 weeks. PANSS was assessed at baseline and a 12-week follow-up. Plasma TAOC levels were also assayed at baseline and week 12.
Relative to nonsmokers with ANFE SZ, smokers had higher PANSS negative subscores. There was no significant difference in TAOC changes after 12 weeks of treatment with risperidone between smokers and non-smokers. However, we found greater improvement in negative symptoms in smokers compared to non-smokers. Further analysis in smokers with SZ demonstrated that improvements in negative symptoms were not associated with changes in TAOC.
Our study suggested that smoking affected the severity of baseline negative symptoms and further contributed to their reduction after risperidone treatment. However, improvement in negative symptoms was not dependent on the changes in TAOC.
有假设认为吸烟与阴性症状的严重程度相关。迄今为止，尚无研究调查吸烟对阴性症状的影响是否取决于抗氧化剂。本研究旨在评估吸烟对初发未使用抗精神病药物的首发（ANFE）患者治疗反应和总抗氧化能力（TAOC）的影响。
使用阳性和阴性症状量表（PANSS）评估患者症状的严重程度。共招募了237例ANFE患者，并用利培酮（口服片剂，4 - 6毫克/天，每日两次）治疗12周。在基线和12周随访时评估PANSS。还在基线和第12周测定血浆TAOC水平。
相对于ANFE精神分裂症的非吸烟者，吸烟者的PANSS阴性子评分更高。吸烟者和非吸烟者在使用利培酮治疗12周后TAOC变化无显著差异。然而，我们发现吸烟者的阴性症状改善程度大于非吸烟者。对精神分裂症吸烟者的进一步分析表明，阴性症状的改善与TAOC的变化无关。
我们的研究表明，吸烟影响基线阴性症状的严重程度，并在利培酮治疗后进一步促进其减轻。然而，阴性症状的改善并不取决于TAOC的变化。
