Mu Xishu, Wu Wenjing, Wang Sisi, Su Xiuru, Guan Hengyong, Guan Xiaoni, Lu Xiaobing, Li Zezhi
Hebei Province Veterans Hospital, Baoding, China.
Qingdao Mental Health Center, Qingdao, China.
Schizophrenia (Heidelb). 2024 Mar 15;10(1):34. doi: 10.1038/s41537-024-00449-1.
Patients with schizophrenia (SCZ) smoke up to three times more than general people. However, there are conflicting results regarding the relationship between tobacco smoke and clinical symptom severity in SCZ. The aim of this study was to assess the impact of smoking on clinical symptoms after antipsychotic treatment in a 12-week cohort study after controlling for confounding factors. One hundred and forty-five male patients with drug-naïve first-episode (DNFE) SCZ received antipsychotic monotherapy for 12 weeks. Symptom severity was assessed at baseline and at week 12 by the Positive and Negative Syndrome Scale (PANSS). We found no differences in clinical symptoms among male smokers with SCZ compared with male nonsmokers. However, male smokers showed greater improvement in negative symptoms after 12 weeks of treatment, controlling for age, years of education, onset age, and baseline body mass index (BMI). Our study showed that after 12 weeks of treatment with antipsychotics, male smokers showed greater improvement in negative symptoms than male nonsmokers.
精神分裂症（SCZ）患者的吸烟量比普通人多两倍。然而，关于烟草烟雾与SCZ临床症状严重程度之间的关系，研究结果存在矛盾。本研究的目的是在一项为期12周的队列研究中，在控制混杂因素后，评估吸烟对接受抗精神病药物治疗后临床症状的影响。145例首次发作未用药（DNFE）的男性SCZ患者接受了12周的抗精神病药物单一疗法。在基线和第12周时，通过阳性和阴性症状量表（PANSS）评估症状严重程度。我们发现，与男性非吸烟者相比，男性SCZ吸烟者的临床症状没有差异。然而，在控制了年龄、受教育年限、发病年龄和基线体重指数（BMI）后，男性吸烟者在治疗12周后的阴性症状有更大改善。我们的研究表明，在接受抗精神病药物治疗12周后，男性吸烟者的阴性症状改善程度比男性非吸烟者更大。
