Yang Lumin, Zhao Xiaoduo, Liao Xiaozhu, Wang Rui, Fan Zengjie, Ma Shuanhong, Zhou Feng
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Shandong Laboratory of Yantai Advanced Materials and Green Manufacture, Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering, Yantai 264006, China.
J Colloid Interface Sci. 2023 Jan;629(Pt B):859-870. doi: 10.1016/j.jcis.2022.09.098. Epub 2022 Sep 24.
The lubrication deficiency in joints is a major cause of osteoarthritis. One of the most commonly used treatment means is to inject artificial lubricants, but there is a potential risk of infection during the injection process. Therefore, developing artificial lubricants with dual functions of friction-reduction and antibacterial is urgent. In this work, a novel polysaccharide-derived lubricant with simultaneous anti-bacteria and water-lubrication properties, called CS-MPC-N, is developed by grafting 2‑methacryloyloxylethyl phosphorylcholine (MPC) and nisin peptide onto backbone of chitosan (CS). Compared to the control CS, CS-MPC-N exhibits good lubrication and friction-reduction properties because of its excellent water solubility. Especially, CS-MPC-N shows low friction coefficient (0.03 ∼ 0.05) at the sliding interfaces of artificial joints materials or even natural articular cartilages. Moreover, CS-MPC-N can effectively inhibit the proliferation of Staphylococcus aureu, exhibiting excellent antibacterial effect. This kind of novel polysaccharide-derived lubricant is expected to be used in treating infectious arthritis.
关节润滑不足是骨关节炎的主要原因之一。最常用的治疗方法之一是注射人工润滑剂，但注射过程中存在感染的潜在风险。因此，开发具有减摩和抗菌双重功能的人工润滑剂迫在眉睫。在这项工作中，通过将2-甲基丙烯酰氧乙基磷酰胆碱（MPC）和乳链菌肽肽接枝到壳聚糖（CS）主链上，开发了一种具有抗菌和水润滑双重性能的新型多糖基润滑剂，称为CS-MPC-N。与对照CS相比，CS-MPC-N由于其优异的水溶性而表现出良好的润滑和减摩性能。特别是，CS-MPC-N在人工关节材料甚至天然关节软骨的滑动界面处显示出低摩擦系数（0.03～0.05）。此外，CS-MPC-N能有效抑制金黄色葡萄球菌的增殖，表现出优异的抗菌效果。这种新型多糖基润滑剂有望用于治疗感染性关节炎。
