State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, China.
Adv Healthc Mater. 2022 Jul;11(13):e2200090. doi: 10.1002/adhm.202200090. Epub 2022 Apr 13.
Developing highly efficient and biocompatible biolubricants for arthritis treatment is extraordinarily demanded. Herein, inspired by the efficient lubrication of synovial joints, a paradigm that combines natural polysaccharide (chitosan) with zwitterionic poly[2-(methacryloyloxy) ethyl phosphorylcholine] (PMPC), to design a series of brush-like Chitosan-g-PMPC copolymers with highly efficient biological lubrication and good biocompatibility is presented. The Chitosan-g-PMPC copolymers are prepared via facile one-step graft polymerization in aqueous medium without using any toxic catalysts and organic solvents. The as-prepared Chitosan-g-PMPC copolymers exhibit very low coefficient of friction (μ < 0.01) on Ti Al V alloy substrate in both pure water and biological fluids. The superior lubrication is attributed primarily to the hydrated feature of PMPC side chains, interface adsorption of copolymer as well as to the hydrodynamic effect. In vivo experiments confirm that Chitosan-g-PMPC can alleviate the swelling symptom of arthritis and protect the bone and cartilage from destruction. Due to their facile preparation, distinctive lubrication properties, and good biocompatibility, Chitosan-g-PMPC copolymers represent a new type of biomimetic lubricants derived from natural biopolymer for promising arthritis treatment and artificial joint lubrication.
开发高效且生物相容的生物润滑剂来治疗关节炎的需求极高。受滑膜关节高效润滑的启发，本研究设计了一系列具有高效生物润滑和良好生物相容性的新型多糖（壳聚糖）与两性离子聚[2-(甲基丙烯酰氧)乙基磷酸胆碱]（PMPC）相结合的刷状壳聚糖-g-PMPC 共聚物。该共聚物可通过在水相介质中简便的一步接枝聚合反应制备，无需使用任何有毒催化剂和有机溶剂。在 Ti Al V 合金基底上，所制备的壳聚糖-g-PMPC 共聚物在纯水和生物流体中均表现出非常低的摩擦系数（μ<0.01）。优异的润滑性能主要归因于 PMPC 侧链的水合特性、共聚物的界面吸附以及流体动力效应。体内实验证实，壳聚糖-g-PMPC 可以减轻关节炎的肿胀症状，并保护骨骼和软骨免受破坏。由于其简便的制备方法、独特的润滑性能和良好的生物相容性，壳聚糖-g-PMPC 共聚物为治疗关节炎和人工关节润滑提供了一种有前途的新型仿生天然生物聚合物衍生的生物润滑剂。
