Silvestrini G, Ferraccioli G F, Quaini F, Palummeri E, Bonucci E
Appl Pathol. 1987;5(3):184-9.
Bone biopsies from 2 adult cases of benign osteopetrosis have been studied histologically and under the electron microscope. The most important findings were a high degree of osteosclerosis, narrowing and fibrosis of medullary spaces, and the presence of abundant uncalcified osteoid tissue with an osteomalacia-like appearance. The osteoclasts were not numerous. All of them lacked the brush border and many showed wide cytoplasmic vacuoles containing amorphous and filamentous material. This picture, which is not different from that found in cases of fetal osteopetrosis, has not been modified by ethydronate therapy.
对2例成人良性骨硬化症患者的骨活检组织进行了组织学和电子显微镜研究。最重要的发现是高度骨硬化、髓腔狭窄和纤维化，以及存在大量外观类似骨软化症的未钙化类骨质组织。破骨细胞数量不多。所有破骨细胞均缺乏刷状缘，许多破骨细胞显示含有无定形和丝状物质的宽大胞质空泡。这种情况与胎儿骨硬化症病例中发现的情况并无不同，依替膦酸盐治疗并未改变这种情况。
