异恶酰胺-阿司匹林组合对大鼠聚氨酯海绵植入模型的影响。
The effect of isoxicam-aspirin combinations on the polyurethane sponge implantation model in the rat.
作者信息
Garrett R, Manthey B, Vernon-Roberts B, Brooks P M
出版信息
Br J Clin Pharmacol. 1986;22 Suppl 2(Suppl 2):125S-128S. doi: 10.1111/j.1365-2125.1986.tb02993.x.
Abstract
1 Anti-inflammatory effects of isoxicam alone and in combination with aspirin were studied in rats using the polyurethane sponge implantation model of acute inflammation. 2 Dose-response studies were performed to delineate a suppressive (high) and non-suppressive (low) dose of isoxicam prior to studying these doses in combination with aspirin. 3 The results indicate that a combination of aspirin with isoxicam does not have an additive anti-inflammatory effect. 4 The interference demonstrated by aspirin with the anti-inflammatory effects of other NSAIDs such as indomethacin is also demonstrated with aspirin/isoxicam combinations.
摘要
- 使用急性炎症的聚氨酯海绵植入模型，在大鼠中研究了异恶酰胺单独使用及与阿司匹林联合使用的抗炎作用。2. 在研究这些剂量与阿司匹林联合使用之前，进行了剂量反应研究以确定异恶酰胺的抑制性（高）剂量和非抑制性（低）剂量。3. 结果表明，阿司匹林与异恶酰胺联合使用不具有相加抗炎作用。4. 阿司匹林对其他非甾体抗炎药（如吲哚美辛）抗炎作用的干扰，在阿司匹林/异恶酰胺组合中也得到了证实。
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Br J Clin Pharmacol. 1986;22 Suppl 2(Suppl 2):125S-128S. doi: 10.1111/j.1365-2125.1986.tb02993.x.
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引用本文的文献
1
Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA.巴利·弗农-罗伯茨教授，AO，医学博士，理学学士，哲学博士，FRCPath，FRCPA，FAOrthA（荣誉），FRS.SA。
Inflammopharmacology. 2013 Aug;21(4):269-77. doi: 10.1007/s10787-013-0176-6. Epub 2013 Jul 4.
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Interaction between flurbiprofen and indomethacin in rheumatoid arthritis.氟比洛芬与吲哚美辛在类风湿性关节炎中的相互作用。
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Assessment of nonsteroidal anti-inflammatory drug combinations by the polyurethane sponge implantation model in the rat.通过大鼠聚氨酯海绵植入模型评估非甾体抗炎药组合。
Ann Rheum Dis. 1983 Aug;42(4):439-42. doi: 10.1136/ard.42.4.439.
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Naproxen-aspirin interactions in man.萘普生与阿司匹林在人体中的相互作用。
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