通过大鼠聚氨酯海绵植入模型评估非甾体抗炎药组合。
Assessment of nonsteroidal anti-inflammatory drug combinations by the polyurethane sponge implantation model in the rat.
作者信息
Garrett R, Manthey B, Vernon-Roberts B, Brooks P M
出版信息
Ann Rheum Dis. 1983 Aug;42(4):439-42. doi: 10.1136/ard.42.4.439.
Abstract
The anti-inflammatory effect of single doses and combinations of aspirin and commonly used nonsteroidal anti-inflammatory drugs was investigated by the polyurethane sponge implantation model of acute inflammation. Dose response curves were performed to delineate a suppressive (high) and nonsuppressive (low) dose of each drug prior to studying these doses in combination with aspirin. The results suggest that a combination of aspirin in either high or low dose does not increase the anti-inflammatory effect of other nonsteroidal anti-inflammatory drugs in this model of inflammation.
摘要
通过聚氨酯海绵植入急性炎症模型，研究了单剂量以及阿司匹林与常用非甾体抗炎药组合的抗炎作用。在研究这些药物与阿司匹林联合使用之前，绘制剂量反应曲线以确定每种药物的抑制性（高）剂量和非抑制性（低）剂量。结果表明，在该炎症模型中，高剂量或低剂量的阿司匹林与其他非甾体抗炎药联合使用均不会增强其抗炎效果。
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