甲硝唑对健康受试者茶碱代谢无抑制作用。
Lack of inhibitory effect of metronidazole on theophylline disposition in healthy subjects.
作者信息
Adebayo G I, Mabadeje A F
出版信息
Br J Clin Pharmacol. 1987 Jul;24(1):110-3. doi: 10.1111/j.1365-2125.1987.tb03146.x.
Abstract
The effect of metronidazole, at a dose of 1.2 g daily, on theophylline disposition was studied in 10 healthy adult volunteers. Neither theophylline half-life, volume of distribution nor total body clearance was altered by the anti-microbial. It is concluded that metronidazole does not impair theophylline metabolism despite the fact that it is a substituted imidazole.
摘要
在10名健康成年志愿者中研究了每日剂量为1.2克的甲硝唑对茶碱处置的影响。抗菌药物对茶碱的半衰期、分布容积或全身清除率均无改变。得出的结论是，尽管甲硝唑是一种取代咪唑，但它并不损害茶碱的代谢。
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