右丙氧芬对人体氧化药物代谢抑制作用的特异性：对茶碱和甲苯磺丁脲处置的影响。
Specificity of the inhibitory effect of dextropropoxyphene on oxidative drug metabolism in man: effects on theophylline and tolbutamide disposition.
作者信息
Robson R A, Miners J O, Whitehead A G, Birkett D J
出版信息
Br J Clin Pharmacol. 1987 Jun;23(6):772-5. doi: 10.1111/j.1365-2125.1987.tb03115.x.
Abstract
Two groups of six healthy male volunteers were studied to assess the possibility of an interaction between dextropropoxyphene and theophylline or tolbutamide using a randomised, crossover design. Subjects received theophylline 125 mg 8 hourly or tolbutamide 500 mg i.v. with and without dextropropoxyphene hydrochloride 65 mg 8 hourly. Theophylline 8-hydroxylation was reduced by a mean of 17% but there were no changes in theophylline 1-demethylation, theophylline 3-demethylation or tolbutamide hydroxylation.
摘要
两组各六名健康男性志愿者参与了研究，采用随机交叉设计来评估右丙氧芬与茶碱或甲苯磺丁脲之间相互作用的可能性。受试者每8小时接受125毫克茶碱或静脉注射500毫克甲苯磺丁脲，同时分别有或没有每8小时65毫克盐酸右丙氧芬。茶碱8-羟化平均降低了17%，但茶碱1-去甲基化、茶碱3-去甲基化或甲苯磺丁脲羟化均无变化。
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