Department of Anesthesiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Biomed Res Int. 2022 Sep 27;2022:6414722. doi: 10.1155/2022/6414722. eCollection 2022.
The effects of Rimazolam on oxidative stress level, sedation score, and recovery time of patients under different doses in hip replacement are investigated. A total of 100 patients who underwent hip arthroplasty in our hospital from September 2020 to May 2022 are selected as the study subjects. According to the random number table method, they are divided into observation group and control group. The observation group is given 0.3 mg/kg Rimazolam, and the control group is given 0.4 mg/kg Rimazolam. Oxidative stress level, hemodynamic indexes at different time after anesthesia, sedation score and sedation depth, Visual Analogue Scale/Score (VAS) score and incidence of adverse reactions are observed in 2 groups. The correlation of sedation score with oxidative stress index and pain degree is analyzed. The experimental results show that Rimazolam has a good anesthesia induction effect in hip replacement, but the low dose (0.3 mg/kg) can reduce the level of oxidative stress in patients, has a better sedation effect and can maintain the stability of patients' hemodynamic indicators, and has a positive effect on relieving postoperative pain in patients. [Clinical Trial Registration Number- ChiCTR2000038548].
研究瑞马唑仑对不同剂量髋关节置换患者氧化应激水平、镇静评分和恢复时间的影响。选择 2020 年 9 月至 2022 年 5 月在我院行髋关节置换术的 100 例患者为研究对象。根据随机数字表法分为观察组和对照组。观察组给予 0.3mg/kg 瑞马唑仑，对照组给予 0.4mg/kg 瑞马唑仑。观察两组患者的氧化应激水平、麻醉后不同时间的血流动力学指标、镇静评分和镇静深度、视觉模拟评分/评分（VAS）和不良反应发生率。分析镇静评分与氧化应激指标和疼痛程度的相关性。实验结果表明，瑞马唑仑在髋关节置换术中具有良好的麻醉诱导作用，但低剂量（0.3mg/kg）可降低患者的氧化应激水平，镇静效果更好，能维持患者血流动力学指标的稳定性，对缓解患者术后疼痛有积极作用。[临床试验注册号- ChiCTR2000038548]。
