Bowman Thomas Patrick, Deshpande Ashutosh, Balfour Alison, Harvey-Wood Kathleen
Department of Microbiology Queen Elizabeth University Hospital Glasgow UK.
Pediatr Investig. 2022 Sep 8;6(3):163-170. doi: 10.1002/ped4.12345. eCollection 2022 Sep.
() is a coagulase-negative staphylococcus (CoNS), found commonly as skin flora in humans. While most species of CoNS are clinically benign, can exhibit a similar virulence to that of . However, there is scant data concerning infection in the pediatric population.
To ascertain local infection rates and sensitivity patterns in the pediatric population.
A retrospective analysis was undertaken of all isolates across a 6-year period from 2015 to 2020. Data were collected from electronic patient notes and laboratory records. Matrix-assisted laser desorption ionization and time of flight mass spectrometry were used to identify isolates.
Ninety-six isolates of were identified from 86 patients. Of these, 34 isolates were treated as an infection. Twenty-three (67.6%) were found to have skin as the primary source of infection. While the observed number was small, central nervous system (CNS) sources of infection appear to be a significant source: all three isolates cultured from cerebrospinal fluid were clinically managed as infection. All three were associated with ventriculoperitoneal (VP) shunt infection. No cases of infective endocarditis were identified. About 18.6% of isolates were resistant to flucloxacillin.
is an uncommon but significant cause of infection in the pediatric population and appears to be a rising cause of CNS infection, particularly when associated with VP shunts. Flucloxacillin is recommended locally as the first choice of antibiotic.
（某菌名）是一种凝固酶阴性葡萄球菌（CoNS），常见于人类皮肤菌群。虽然大多数CoNS菌种在临床上是良性的，但（某菌名）可表现出与（另一菌名）相似的毒力。然而，关于儿科人群中（某菌名）感染的数据很少。
确定儿科人群中（某菌名）的局部感染率和敏感性模式。
对2015年至2020年6年间所有（某菌名）分离株进行回顾性分析。数据从电子病历和实验室记录中收集。使用基质辅助激光解吸电离和飞行时间质谱法鉴定分离株。
从86例患者中鉴定出96株（某菌名）。其中，34株分离株被视为感染。发现23株（67.6%）的主要感染源为皮肤。虽然观察到的数量较少，但（某菌名）感染的中枢神经系统（CNS）来源似乎是一个重要来源：从脑脊液中培养出的所有3株分离株在临床上都被作为感染进行处理。所有3株都与脑室腹腔（VP）分流感染有关。未发现（某菌名）感染性心内膜炎病例。约18.6%的（某菌名）分离株对氟氯西林耐药。
（某菌名）是儿科人群中一种不常见但重要的感染原因，似乎是中枢神经系统感染的一个日益增加的原因，特别是与VP分流相关时。在当地，氟氯西林被推荐为首选抗生素。
