Faculty of Medicine, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel.
Department of Paediatrics, Hadassah-Hebrew University Medical Centre, Jerusalem.
J Med Microbiol. 2021 May;70(5). doi: 10.1099/jmm.0.001357.
(SL), a tube coagulase negative , is known to be pathogenic in adults, causing mainly skin infections. Previous studies assessing SL's role in paediatric populations are sparse and are mainly limited to case reports. Present the clinical characteristics consistent with SL infections and its putative role as a pathogen in the paediatric population. A retrospective multicentre study was conducted in four paediatric medical centres in Israel. Patients with isolates of SL presenting between 2009-2019 were included. SL was isolated from 40 patients. Average (±SD) age at presentation was 5.9 (±6.2) years, with 22 (55 %) being female. Skin, soft tissue and musculoskeletal infections were the most common (=20, 50%) followed by ear infections (=13, 32.5%). Five cases of urine isolates and two isolates from blood culture samples were also reported. Skin abscess was the most common infection among skin and soft tissue isolates, reported in 17 children (85%) with SL being the only pathogen in 15 (75%). Otitis media was the most common ear infection accounting for 12 (92%) of all cases with SL as the only isolate reported in 6 (46%). Five cases of SL isolates from urine specimens were reported, all of which with poor growth of bacteria and normal urinalysis. Two cases of SL growth in blood culture were found in children presenting with signs and symptoms consistent with invasive blood stream infection. In the paediatric population, studied infections caused by SL are increasingly observed. The results of this study highlight its role as a pathogen in soft tissue infections and its putative role in otitis media and invasive blood stream infections. However, the role of SL as an uropathogen was not established.
（SL）是一种凝固酶阴性的管状菌，已知在成人中具有致病性，主要引起皮肤感染。以前评估 SL 在儿科人群中作用的研究很少，并且主要限于病例报告。本研究旨在介绍与 SL 感染一致的临床特征及其在儿科人群中作为病原体的潜在作用。本研究是在以色列的 4 个儿科医学中心进行的回顾性多中心研究。纳入了 2009 年至 2019 年间分离出 SL 的患者。从 40 名患者中分离出 SL。平均（±SD）就诊年龄为 5.9（±6.2）岁，其中 22 名（55%）为女性。皮肤、软组织和肌肉骨骼感染最为常见（=20，50%），其次是耳部感染（=13，32.5%）。还报告了 5 例尿分离株和 2 例血培养样本分离株。皮肤脓肿是皮肤和软组织分离株中最常见的感染，17 名儿童（85%）中存在 SL，其中 15 名（75%）只有 SL 一种病原体。中耳炎是最常见的耳部感染，共 12 例（92%），其中 6 例（46%）仅报告 SL 为唯一分离株。报告了 5 例来自尿液标本的 SL 分离株，所有标本均存在细菌生长不良和正常尿液分析。在有侵袭性血流感染的症状和体征的儿童中发现了 2 例血培养中 SL 生长的病例。在儿科人群中，研究发现 SL 引起的感染越来越多。本研究结果强调了其在软组织感染中的病原体作用，以及在中耳炎和侵袭性血流感染中的潜在作用。然而，SL 作为尿病原体的作用尚未确定。
