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斜视手术后使用局部地塞米松眼膏后眼压升高

Intraocular Pressure Elevation Following the Use of Topical Dexamethasone Ointment After Squint Surgery.

作者信息

Ugalahi Mary O, Ibukun Folahan A, Olusanya Bolutife A, Baiyeroju Aderonke M

机构信息

Department of Ophthalmology, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.

Department of Ophthalmology, University College Hospital, Ibadan, Nigeria.

出版信息

J West Afr Coll Surg. 2022 Jan-Mar;12(1):70-75. doi: 10.4103/jwas.jwas_26_22. Epub 2022 Aug 23.

DOI:10.4103/jwas.jwas_26_22
PMID:36203922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9531743/
Abstract

PURPOSE

To describe the pattern of intraocular pressure (IOP) changes after squint surgery in eyes of black Africans at the University College Hospital, Ibadan, Nigeria.

MATERIALS AND METHODS

This was a retrospective review of the clinical records of patients who underwent squint surgery between 2010 and 2019. Data on demographic characteristics, preoperative and postoperative intraocular pressure values, co-existing ocular pathology, type of strabismus, surgery performed, frequency and duration of postoperative topical steroid use and treatment received for elevated intraocular pressure were collected and descriptively summarised.

RESULTS

Thirty-six (39.1%) out of 92 patients who had squint surgery during the study period met study inclusion criteria. Mean age was 20.5 ± 13.6 years. All patients were administered Maxitrol® ointment postoperatively. Baseline, peak and net change in IOP were 12.9 ± 2.6 mmHg, 21.3 ± 6.8 mmHg and 8.39 ± 7.2 mmHg respectively. Thirty-one (86.1%) patients had elevation in IOP from baseline; 21 (67.7%) of these had significant IOP elevation. Topical steroid therapy was tailed off rapidly for all patients with significant IOP elevation. Twelve patients were commenced on topical IOP lowering medications, with normalization of intraocular pressure in majority of them by three months after surgery.

CONCLUSION

Elevated intraocular pressure with the use of topical dexamethasone ointment after squint surgery was common in this study and majority of the patients had significant elevation in intraocular pressure. Close monitoring of the intraocular pressure of black patients, especially children, on topical steroid medication after squint surgery is strongly recommended.

摘要

目的

描述在尼日利亚伊巴丹大学学院医院,非洲黑人患者斜视手术后眼压(IOP)的变化模式。

材料与方法

这是一项对2010年至2019年间接受斜视手术患者临床记录的回顾性研究。收集了关于人口统计学特征、术前和术后眼压值、并存的眼部病变、斜视类型、所施行的手术、术后局部使用类固醇的频率和持续时间以及针对眼压升高所接受治疗的数据,并进行描述性总结。

结果

在研究期间接受斜视手术的92例患者中,36例(39.1%)符合研究纳入标准。平均年龄为20.5±13.6岁。所有患者术后均使用Maxitrol®眼膏。眼压的基线值、峰值和净变化分别为12.9±2.6 mmHg、21.3±6.8 mmHg和8.39±7.2 mmHg。31例(86.1%)患者眼压较基线升高;其中21例(67.7%)眼压显著升高。对于所有眼压显著升高的患者,局部类固醇治疗迅速减量。12例患者开始使用局部降眼压药物,大多数患者在术后三个月眼压恢复正常。

结论

本研究中斜视手术后使用局部地塞米松眼膏导致眼压升高较为常见,大多数患者眼压显著升高。强烈建议密切监测斜视手术后使用局部类固醇药物的黑人患者,尤其是儿童的眼压。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74e3/9531743/ad313ec2ec3d/JWACS-12-70-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74e3/9531743/a98c75b26ef0/JWACS-12-70-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74e3/9531743/cf35b94904fc/JWACS-12-70-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74e3/9531743/ad313ec2ec3d/JWACS-12-70-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74e3/9531743/a98c75b26ef0/JWACS-12-70-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74e3/9531743/cf35b94904fc/JWACS-12-70-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74e3/9531743/ad313ec2ec3d/JWACS-12-70-g003.jpg

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本文引用的文献

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Intraocular pressure elevation associated with blood in Schlemm's canal after strabismus surgery.斜视手术后施莱姆管内血液导致的眼压升高
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Risk of intraocular pressure elevation after topical steroids in children and adults: A systematic review.儿童和成人局部使用类固醇后眼压升高的风险:一项系统评价。
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Effect of strabismus surgery on ocular axial length, anterior chamber depth, and intraocular pressure.
斜视手术对眼轴长度、前房深度和眼压的影响。
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J Ocul Pharmacol Ther. 2018 Sep;34(7):550-554. doi: 10.1089/jop.2018.0003. Epub 2018 May 21.
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