Huang Binyao, Wang Xiaolu, Jiang Biao, Kong Linlin, Hou Haifeng, Zhou Jiong
School of Foreign Languages, Zhejiang University of Finance and Economics, Hangzhou, China.
School of Foreign Languages, Zhejiang University City College, Hangzhou, China.
Front Neurol. 2022 Sep 20;13:963970. doi: 10.3389/fneur.2022.963970. eCollection 2022.
Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease, is characterized by a progressive loss of specific language functions while other cognitive domains are relatively unaffected. The logopenic variant, characterized by impairments of word retrieval and sentence repetition along with preserved semantic, syntactic, and motor speech abilities, is the most recently described and remains less understood than other variants due to a comparatively small number of case studies and a lack of investigations with a thorough specification. In this article, we report a 2-year follow-up case study of a 74-year-old Chinese female patient with a logopenic variant of primary progressive aphasia, including its neurolinguistic study, magnetic resonance imaging (MRI), and 11C-Pittsburgh compound B-Positron emission tomography imaging analyses, as well as gene sequencing. This case confirms that, in addition to word-finding and sentence repetition difficulties, the logopenic variant may also present with mild auditory comprehension and naming deficits attributed to impaired access to lexical representations. The observation of clinical treatment suggests the efficacy of memantine hydrochloride tablet and rivastigmine transdermal patch in slowing down the cognitive deterioration of this patient. The description and exploration of this case may shed new insights into a better understanding of the Chinese logopenic variant of primary progressive aphasia.
原发性进行性失语（PPA）通常由神经退行性疾病引起，其特征是特定语言功能逐渐丧失，而其他认知领域相对未受影响。语音性变异型原发性进行性失语的特征是词汇检索和句子复述受损，同时语义、句法和言语运动能力保留，这是最近描述的一种类型，由于病例研究数量相对较少且缺乏全面详细的调查，与其他变异型相比，人们对它的了解仍然较少。在本文中，我们报告了一名74岁中国女性语音性变异型原发性进行性失语患者的2年随访病例研究，包括神经语言学研究、磁共振成像（MRI）、11C-匹兹堡化合物B-正电子发射断层扫描成像分析以及基因测序。该病例证实，除了找词和句子复述困难外，语音性变异型原发性进行性失语还可能表现为轻度听觉理解和命名缺陷，这归因于词汇表征获取受损。临床治疗观察表明，盐酸美金刚片和卡巴拉汀透皮贴剂在减缓该患者认知衰退方面具有疗效。该病例的描述和探索可能为更好地理解中国语音性变异型原发性进行性失语提供新的见解。
