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一名患有代谢综合征的新冠病毒检测呈阳性患者的免疫球蛋白A肾病

Immunoglobulin A Nephropathy in a SARS-CoV-2-Positive Patient With Coexistent Metabolic Syndrome.

作者信息

Kalita Pranjal, Dey Biswajit, Mishra Jaya, Tiewsoh Iadarilang, Raphael Vandana

机构信息

Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, IND.

Internal Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, IND.

出版信息

Cureus. 2022 Sep 3;14(9):e28719. doi: 10.7759/cureus.28719. eCollection 2022 Sep.

Abstract

SARS-CoV-2 viral infection though primarily affects the respiratory system, but concurrent renal involvement is been reported in the medical literature. Acute kidney injury (AKI) is a common finding in SARS-CoV-2-positive patients. An isolated case of IgA nephropathy in a SARS-CoV-2 virus-infected patient has been already reported in the medical literature. Incidence of metabolic syndromes is on the rise considering the change in lifestyle and food habits and the global pandemic of obesity. Renal manifestations of metabolic syndrome are myriad with IgA nephropathy being an occasional manifestation in such patients. We reported a case of IgA nephropathy in a patient in her fourth decade of life diagnosed as metabolic syndrome with concomitant SARS-CoV-2 infection that progressed to chronic kidney damage (CKD) subsequently. In this case report, we postulate that cytokine storm along with hypoxemia secondary to SARS-CoV-2 infection may accelerate the declining renal function however further studies are necessary to confirm this hypothesis considering the rarity of such cases.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染虽然主要影响呼吸系统,但医学文献中已报道有并发肾脏受累的情况。急性肾损伤(AKI)在SARS-CoV-2阳性患者中很常见。医学文献中已经报道了1例SARS-CoV-2病毒感染患者发生孤立性IgA肾病的病例。考虑到生活方式和饮食习惯的改变以及肥胖的全球流行,代谢综合征的发病率正在上升。代谢综合征的肾脏表现多种多样,IgA肾病是这类患者偶尔出现的一种表现。我们报告了1例40多岁的患者,诊断为代谢综合征并伴有SARS-CoV-2感染,随后进展为慢性肾脏损害(CKD),该患者患有IgA肾病。在本病例报告中,我们推测SARS-CoV-2感染继发的细胞因子风暴和低氧血症可能会加速肾功能下降,然而考虑到这类病例的罕见性,需要进一步研究来证实这一假设。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59ad/9527633/e6a431f2d038/cureus-0014-00000028719-i01.jpg

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