Naik Roopa, Avula Sreekant, Palleti Sujith K, Gummadi Jyotsna, Ramachandran Rajarajeshwari, Chandramohan Deepak, Dhillon Gagandeep, Gill Angad S, Paiwal Kapil, Shaik Bushra, Balachandran Malavika, Patel Bhumika, Gurugubelli Simhachalam, Mariswamy Arun Kumar Abhishek Kumar, Nanjundappa Athmananda, Bellamkonda Mahita, Rathi Kanika, Sakhamuri Pavana Lalithya, Nassar Mahmoud, Bali Atul
Medicine, Geisinger Commonwealth School of Medicine, Scranton, USA.
Internal Medicine/Hospital Medicine, Geisinger Health System, Wilkes Barre, USA.
Cureus. 2023 Oct 31;15(10):e48046. doi: 10.7759/cureus.48046. eCollection 2023 Oct.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), later renamed coronavirus disease 2019 (COVID-19), was first identified in Wuhan, China, in early December 2019. Initially, the China office of the World Health Organization was informed of numerous cases of pneumonia of unidentified etiology in Wuhan, Hubei Province at the end of 2019. This would subsequently result in a global pandemic with millions of confirmed cases of COVID-19 and millions of deaths reported to the WHO. We have analyzed most of the data published since the beginning of the pandemic to compile this comprehensive review of SARS-CoV-2. We looked at the core ideas, such as the etiology, epidemiology, pathogenesis, clinical symptoms, diagnostics, histopathologic findings, consequences, therapies, and vaccines. We have also included the long-term effects and myths associated with some therapeutics of COVID-19. This study presents a comprehensive assessment of the SARS-CoV-2 virology, vaccines, medicines, and significant variants identified during the course of the pandemic. Our review article is intended to provide medical practitioners with a better understanding of the fundamental sciences, clinical treatment, and prevention of COVID-19. As of May 2023, this paper contains the most recent data made accessible.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2），后更名为2019冠状病毒病（COVID-19），于2019年12月初在中国武汉首次被发现。最初，世界卫生组织中国办公室于2019年底接到通报，湖北省武汉市出现多例病因不明的肺炎病例。这随后导致了一场全球大流行，向世界卫生组织报告的COVID-19确诊病例数以百万计，死亡人数也数以百万计。我们分析了自大流行开始以来发布的大部分数据，以编写这份关于SARS-CoV-2的全面综述。我们研究了其核心要点，如病因、流行病学、发病机制、临床症状、诊断、组织病理学发现、后果、治疗方法和疫苗。我们还纳入了与COVID-19某些治疗方法相关的长期影响和误解。本研究对大流行期间发现的SARS-CoV-2病毒学、疫苗、药物和重要变种进行了全面评估。我们的综述文章旨在让医学从业者更好地了解COVID-19的基础科学、临床治疗和预防。截至2023年5月，本文包含了可获取的最新数据。
