Li Xinyi, He Wenfei, Zhang Xiaonan, Shu Fen, Liu Yaoxin, Tan Ning, Jiang Lei
Department of Cardiology, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, China.
Department of Cardiology, Guangdong Provincial People's Hospital's Nanhai Hospital, The Second People's Hospital of Nanhai District, Foshan, China.
Front Cardiovasc Med. 2022 Sep 20;9:995899. doi: 10.3389/fcvm.2022.995899. eCollection 2022.
Previous Study Found That Implantation of a Cardioverter-Defibrillator Likely Caused a Worse Prognosis in Older Patients With non-Ischemic Systolic Heart Failure. This Suggests That More Precise Risk Stratification Is Needed in Elderly Patients. We Conducted a Retrospective Study to Evaluate the Association of α-Hydroxybutyrate Dehydrogenase (α-HBDH) With Mortality During Hospitalization in Elderly Patients With non-Ischemic Dilated Cardiomyopathy (NIDCM).
1,019 Elderly Patients (age ≥60 Years) Diagnosed With NIDCM Were Retrospectively Enrolled From January 2010 to December 2019. Univariate and Multivariate Analyses Were Showed to Explore the Relationship Between α-HBDH and in- Hospital Death.
Patients in elevated α-HBDH group (>182 U/L) had a longer hospital stays and higher in-hospital mortality. Univariate logistics regression analysis showed that elevated α-HBDH was significantly related to mortality (OR: 7.004, 95% CI: 3.583-13.693, < 0.001). Receiver operator characteristic (ROC) curve analysis reflected that α-HBDH levels had excellent predictive power for in-hospital death (AUC = 0.810, 95% CI: 0.745-0.876, < 0.001). After adjustment of age, serum creatine, albumin and LVEF, multivariate regression analysis validated the association of elevated α-HBDH with increased risk of in-hospital death ( < 0.05).
Elevated α-HBDH level is significantly related to in-hospital mortality in older patients with NIDCM.
先前的研究发现，植入心脏复律除颤器可能会使老年非缺血性收缩性心力衰竭患者的预后更差。这表明老年患者需要更精确的风险分层。我们进行了一项回顾性研究，以评估α-羟丁酸脱氢酶（α-HBDH）与老年非缺血性扩张型心肌病（NIDCM）患者住院期间死亡率之间的关联。
回顾性纳入2010年1月至2019年12月期间诊断为NIDCM的1019例老年患者（年龄≥60岁）。采用单因素和多因素分析来探讨α-HBDH与院内死亡之间的关系。
α-HBDH水平升高组（>182 U/L）的患者住院时间更长，院内死亡率更高。单因素逻辑回归分析显示，α-HBDH水平升高与死亡率显著相关（OR：7.004，95%CI：3.583-13.693，P<0.001）。受试者工作特征（ROC）曲线分析表明，α-HBDH水平对院内死亡具有良好的预测能力（AUC = 0.810，95%CI：0.745-0.876，P<0.001）。在调整年龄、血清肌酐、白蛋白和左室射血分数后，多因素回归分析证实α-HBDH水平升高与院内死亡风险增加相关（P<0.05）。
α-HBDH水平升高与老年NIDCM患者的院内死亡率显著相关。
