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肯尼亚慢性羟氯喹使用导致的视网膜毒性。

Retinal Toxicity from Chronic Hydroxychloroquine use in Kenya.

机构信息

Department of Ophthalmology, Kenyatta National Hospital, Nairobi, Kenya.

出版信息

Ann Afr Med. 2022 Jul-Sep;21(3):301-304. doi: 10.4103/aam.aam_118_21.

DOI:10.4103/aam.aam_118_21
PMID:36204922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9671192/
Abstract

Irreversible visual loss due to retinal toxicity is one of the side effects of hydroxychloroquine (HCQ) therapy. The recent outbreak of the novel coronavirus-19 (COVID 19) has seen HCQ proposed as a possible treatment and prophylactic drug, leading to its increased use. Many are unaware of its ocular side effects. We describe a case of HCQ-induced retinopathy in a 46-year-old female who was referred by a rheumatologist for routine eye review.

摘要

由于视网膜毒性导致的不可逆转的视力丧失是羟氯喹 (HCQ) 治疗的副作用之一。最近新型冠状病毒-19 (COVID 19) 的爆发使得 HCQ 被提议作为一种可能的治疗和预防药物，导致其使用增加。许多人不知道它的眼部副作用。我们描述了一例由 46 岁女性 HCQ 诱导的视网膜病变病例，该患者由风湿病学家转诊进行常规眼部检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c49/9671192/d9e02085730f/AAM-21-301-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c49/9671192/64a78b4aa730/AAM-21-301-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c49/9671192/2dc15b5701b1/AAM-21-301-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c49/9671192/d9e02085730f/AAM-21-301-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c49/9671192/64a78b4aa730/AAM-21-301-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c49/9671192/2dc15b5701b1/AAM-21-301-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c49/9671192/d9e02085730f/AAM-21-301-g003.jpg

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1
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本文引用的文献

1
Contested effects and chaotic policies: the 2020 story of (hydroxy) chloroquine for treating COVID-19.有争议的效果与混乱的政策：2020年（羟）氯喹治疗新冠病毒病的故事
Cochrane Database Syst Rev. 2021 Mar 25;3(3):ED000151. doi: 10.1002/14651858.ED000151.
2
Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19.氯喹或羟氯喹预防和治疗 COVID-19。
Cochrane Database Syst Rev. 2021 Feb 12;2(2):CD013587. doi: 10.1002/14651858.CD013587.pub2.
3
Choroidal Thinning Associated With Hydroxychloroquine Retinopathy.
与羟氯喹视网膜病变相关的脉络膜变薄
Am J Ophthalmol. 2017 Nov;183:56-64. doi: 10.1016/j.ajo.2017.08.022. Epub 2017 Sep 8.
4
Hydroxychloroquine retinopathy.羟氯喹视网膜病变
Eye (Lond). 2017 Jun;31(6):828-845. doi: 10.1038/eye.2016.298. Epub 2017 Mar 10.
5
The Role of Multifocal Electroretinography in the Assessment of Drug-Induced Retinopathy: A Review of the Literature.多焦视网膜电图在药物性视网膜病变评估中的作用：文献综述
Ophthalmic Res. 2016;56(4):169-177. doi: 10.1159/000446321. Epub 2016 Jun 29.
6
Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy (2016 Revision).关于氯喹和羟氯喹视网膜病变筛查的建议（2016 年修订版）。
Ophthalmology. 2016 Jun;123(6):1386-94. doi: 10.1016/j.ophtha.2016.01.058. Epub 2016 Mar 16.
7
The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy.长期羟氯喹治疗患者中毒性视网膜病变的风险。
JAMA Ophthalmol. 2014 Dec;132(12):1453-60. doi: 10.1001/jamaophthalmol.2014.3459.
8
Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy.与羟氯喹和氯喹相关的视网膜毒性：危险因素、筛查以及尽管停止治疗仍会进展的情况。
Arch Ophthalmol. 2011 Jan;129(1):30-9. doi: 10.1001/archophthalmol.2010.321.
9
Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus.类风湿关节炎和系统性红斑狼疮患者羟氯喹视网膜毒性的发生率及预测因素。
Arthritis Care Res (Hoboken). 2010 Jun;62(6):775-84. doi: 10.1002/acr.20133.
10
Multifocal electroretinographic changes in patients receiving hydroxychloroquine therapy.接受羟氯喹治疗患者的多焦视网膜电图变化。
Am J Ophthalmol. 2005 Nov;140(5):794-807. doi: 10.1016/j.ajo.2005.05.046.