University Hospital of Tours, Department of Pathology, Tours, France.
University Hospital of Tours, Platform of Molecular Genetics, Tours, France.
Histol Histopathol. 2023 Mar;38(3):247-260. doi: 10.14670/HH-18-532. Epub 2022 Oct 7.
Primary aneurysmal bone cyst, nodular fasciitis, myositis ossificans and related lesions as well as fibroma of tendon sheath are benign tumors that share common histological features and a chromosomal rearrangement involving the ubiquitin-specific peptidase 6 (USP6) gene. The tumorigenesis of this tumor spectrum has become complex with the identification of an increasing number of new partners involved in USP6 rearrangements. Because traumatic involvement has long been mentioned in the histogenesis of most lesions in the USP6 spectrum and they morphologically resemble granulation tissue or callus, we attempted to shed light on the function and role USP6 partners play in tissue remodelling and the repair process and, to a lesser extent, bone metabolism.
原发性动脉瘤样骨囊肿、结节性筋膜炎、骨化性肌炎及相关病变和腱鞘纤维瘤均为良性肿瘤，具有共同的组织学特征和涉及泛素特异性肽酶 6（USP6）基因的染色体重排。随着越来越多的新伙伴参与 USP6 重排的鉴定，这个肿瘤谱的肿瘤发生机制变得复杂。由于创伤参与了 USP6 谱中大多数病变的发生机制已有很长时间的提及，并且它们在形态上类似于肉芽组织或骨痂，因此我们试图阐明 USP6 伙伴在组织重塑和修复过程中的功能和作用，以及在较小程度上，骨代谢中的作用。
